Microbiome-Gut-Brain Axis Crosstalk and Clinical Outcomes

Over 2000 years ago, the Greek physician Hippocrates of Kos said, “All disease begins in the gut.” The gut is the most important barrier for environmental factors to interact with our body, knowing that food brings nutrition as well as waste and toxicity. In the mid-19th century, a gastroenterology patient treated by Dr. William Beaumont was the first recorded observation of human digestion taking place in real-time and linking digestion with diseases and emotionality, then was described the gut-brain axis. In recent decades, gut commensal microbiota has emerged as a key regulator of the homeostasis in the gut-brain axis with the studies on Germ-free mouse models. Research about the microbiome-gut-brain axis (MGB) has accelerated at an incredible pace to expand the knowledge of the role of microbiota on the brain and behaviors, from the development of nervous system in early life to mental health and cognitive function, even health aging and longevity.
This research topic aims to disseminate advanced communication among neuroscientists, microbiologists, nutritionists, clinicians, psychiatrists, and psychologists with unique experience and skills, to fulfill the complex puzzle of MGB.
We welcome narrative and systematic reviews (including meta-analyses) and original research studies (pre-clinical, translational, and clinical research). Related themes include the following topics:
- Omics studies that focus on interactions of gut commensal microbiome with host age, gender, gene and gene expression, immune and metabolism system et al., in brain development, health and longevity brain
- Digestion of different types of foods in the gut, nutrients metabolized by gut microbiota, and the gut sensitivity to different types of nutrients and foods
- Central nerve system interactions in gut sensory and individual preference in food
- The chemical, mechanical and electrical communication among gut sensor cells, enteric nerve-vagal nerve system-central nerve system and its role in brain function
- Nutrition and the development of Enteric nerve-vagal nerve system-Central nerve system
- Nutrition and brain function in health and diseases
- Bidirectional interaction among MGB
- Etiology, prevention, and treatment of eating pathologies (e.g., obesity, binge eating, anorexia, bulimia, food addiction)
- Gut microbiome manipulation as the treatment or adjuvant treatment of brain disorders
- Microbiome-based precise medication or personal dietary management for healthy brain