A wide variety of microbial species live in the gut and engage in metabolic and immunological processes. Nutrition, according to recent research, can affect gastrointestinal health by altering gut microbiota and intestinal immune response. Therefore, the components of nutrition play a significant role in developing functional food ideas for the prevention of diseases. Food homologous plants are plants to be used as foods, like Astragalus membranaceus, Momordica charantia, Dendrobium officinale, Mulberry leaf, Premna ligustroides Hemsl, etc., which are rich sources of natural compounds with an ability to influence critical processes such as host metabolism, immunology, and intestinal barrier function. These plants are found naturally in the environment and have nutritive and medicinal effects on the body. The interaction of these natural plants with the gut can aid recovery as well as health maintenance. Hence, the appropriate utilization and proper evaluation of homologous plant resources as health promotion factors are crucial. This research topic intends to encourage original research and review papers that focus on understanding how food homologous plants respond to different health conditions via the gastrointestinal channel.

The purpose of this Research Topic is to collect publications that explain current information about the effects of microbiota on host development, immune response, nutritional transitions, and metabolic disorders under the effect of homologous food plants. The findings may contribute to the development of microbiota-based therapeutics as well as the safety and effectiveness of clinical trials of commercial products in terms of specific nutrient interaction. We hope that this Research Topic will entice many researchers to investigate the mechanistic and functional implications of the gut-disease relation.

We welcome Mini-Reviews, full-length Reviews, and Original Research papers on food homologous plants. Our Research Topic includes, but is not limited to:

1. The interaction of the gut microbiota with dietary components.

2. Gut microbiota modification with a focus on the gut-disease relation.

3. Role of transcription factors in food homologous plants for transcribing specific genes in gut-disease relation.

4. The intraindividual function of gut microbiota and host immune system.

5. Exploring the mechanisms of gut microbiota with homologous plants’ components in different disease conditions.

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Frontiers in Microbiology

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