Chronic inflammation is a component of many disease conditions that affect a large group of individuals worldwide, which is characterized by persistent, low-grade inflammation and is increased in the aging population. It occurs when an initiating stimulus is not removed or if the resolution process is disrupted, resulting in a state of low-grade inflammation. It is acknowledged that chronic inflammatory diseases are involved in cardiovascular diseases, endocrine disease, neurodegenerative disease, hepatic disease, pulmonary disease, gastrointestinal disease, and cancer et al., including but not limited to atherosclerosis, diabetes, multiple sclerosis, fibrosis, NAFLD, COPD, inflammatory bowel disease, autoimmune disorders (like SLE, RA), which are major causes of death worldwide. Therefore, it is necessary to explore novel targets and therapeutic drugs for chronic inflammatory diseases.

The aim of this Research Topic is to investigate the pathogenesis and pathophysiology of chronic inflammatory diseases and focus on therapeutic drugs and natural compounds to discover new therapeutic agents and clinical drugs for the therapy of chronic inflammatory diseases. Through combing clinical data with basic function research of chronic inflammatory diseases, potential new drug targets could be discovered for chronic inflammatory diseases. Therefore, this topic aims to include a study of pathological mechanisms, the evaluation of therapeutic drugs, the screening of new drugs based on new targets, the construction of novel drug delivery systems, early diagnosis, drug development, and the study of sequencing tools.

In this Research Topic, we welcome original research articles, reviews, opinions, perspectives, and systematic reviews, including but not limited to the following themes:

• Research on the pathophysiological mechanisms and novel targets in chronic inflammatory diseases
• Elucidation of mechanisms for therapeutic drugs in chronic inflammatory diseases
• Discovery of new therapeutic drugs and natural compounds for the treatment of chronic inflammatory diseases
• Research on drug transformation and druggability of chronic inflammatory diseases

Please note: only manuscripts reporting on chemically defined compounds (no plant extracts etc.) are accepted.

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Frontiers in Pharmacology

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