Nutraceuticals: Transforming Conventional Foods Into Dietary Medicine for the Clinical Management of Neurodegenerative Diseases and Cancers

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Background

Over the last few years, there has been a growing understanding and knowledge concerning human health and its association with foods. Additionally, the role of natural compounds such as bioactive compounds with their probable function as health promoters has been found to be very important. As a result, diet-based strategies for the management and prevention of various chronic disorders including neurodegenerative diseases and cancer have become more meaningful, leading to the development of nutraceuticals. In broad terms, nutraceuticals are described as a bioactive components present in various foods and play a vital role in human beings by maintaining their normal physiological functions and well-being. Therefore, nutraceuticals could be useful for the maintenance of human health without causing any harm due to their natural origin. Nutraceuticals are generally considered as safe, and daily consumption of these nutraceuticals could help in the management of neurodegenerative diseases and various types of cancers. This research topic will draw the attention of scientific communities to understand the concept of nutraceuticals and their significance in human health, which could serve as an alternative therapy or nutritional pharmacotherapy for the management of several clinical complications.

Clinical significance of nutraceuticals in neurodegenerative diseases and cancer has drastically increased around the world in recent times. Since, an association between food habits and the individual lifestyle with neurodegenerative diseases as well as cancer has been established. Thus, nutraceuticals could play a very important role as prophylactic treatment for neurological interventions and cancer. Furthermore, neurodegenerative disorders and the curative effects of nutraceuticals can be attributed due to their neuroprotective, anti-inflammatory, antioxidant, and healing properties, which can target different ligands and receptors to enhance protein synthesis, leading to neuroprotection. The folding of proteins and their degradation can be inhibited, leading to a healthy nervous system. On the other hand, role of nutraceuticals in cancer cells has been indicated causing inhibition at least experimentally in the initial stages of carcinogenesis. However, as a matter of fact, this area of study still requires further in-depth researches. Therefore, considering the therapeutic advantages of nutraceuticals in the management of cancer and neurodegenerative diseases, this research topic could eventually be proved useful in prospecting for new innovations in the development of nutraceuticals and their clinical significance as a potential therapeutic approaches for the management of cancer and neurodegenerative diseases can be put forward.

In this research topic, we welcome the submission of reviews and original research manuscripts that addresses the recent advancements in the field of nutraceuticals and technological innovations in their development for the management of cancer as well as neurodegenerative diseases. We welcome manuscripts with a focus on the following topics below (but not limited to):

• Recent developments and advancements for the production of nutraceuticals from various sources (plant, animal and microbial).
• Nutraceutical food products derived through fermentation process including prebiotics and probiotics.
• Role of probiotics in the management of cancer.
• Uncovering the potential of nutraceuticals as a targeted therapy against various types of carcinoma.
• Role of nutraceuticals in the clinical management of neurodegenerative disorders and related therapeutic opportunities.
• Mechanistic approaches to recognize the clinical implications of nutraceuticals.
• Current technological approaches and advancements applied in food and pharmaceutical industries for the development of nutraceuticals, as well as to improve the functional capabilities of food bioactive components including its bioavailability, stability, quality, efficacy and its delivery system.
• Last but not the least; use of multi-omics and computational approaches to understand the role of food bioactive compounds present in nutraceuticals, protein-ligand binding interactions and its affinity.

Keywords: Neutraceuticals, functional foods, dietary supplements, metabolic disorders, cancer, neurodegenerative diseases, bioactive compounds, brain health

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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