About this Research Topic
The 'hygiene hypothesis' has been hugely influential for several decades, explaining the noticeable rise in allergy prevalence. According to this hypothesis, the lack of diverse microbial stimulation contributes to the increasing prevalence of allergic diseases.
Lately, there emerges a new hypothesis, the 'epithelial barrier hypothesis' by which hygiene still has a major impact, but instead by the massive introduction of surface-active molecules into the environment, which come into immediate contact with us. Among these molecules are those which disrupt mucosal membranes. These molecules, which are present in allergen sources, are of interest to this topic.
This Research Topic aims to identify - and explore the actions of - mucosal barrier disruptors from original allergen sources. Preferred article types are Original Research and Reviews (Systematic Review, Review, Mini Review), but other article types, such as Methods, Perspective, Data Report, Brief Research Report, General Commentary and Opinion manuscripts will also be reviewed.
Here we invite all researchers working on individual allergen sources to present their research or literature reviews on the topics presented below. In addition, all the data pinpointing individual molecules as mucosal barrier modifying agents are welcomed and this includes both protein and non-protein molecules.
- Barrier disruptors from house dust mites
- Barrier disruptors from food allergen sources
- Barrier disruptors from fruit
- Barrier disruptors from weed pollen
- Barrier disruptors from grass pollen
- Barrier disruptors from tree pollen
- Animal models for monitoring epithelial barrier integrity
- In vitro tests for monitoring epithelial barrier integrity
Lately, there emerges a new hypothesis, the 'epithelial barrier hypothesis' by which hygiene still has a major impact, but instead by the massive introduction of surface-active molecules into the environment, which come into immediate contact with us. Among these molecules are those which disrupt mucosal membranes. These molecules, which are present in allergen sources, are of interest to this topic.
This Research Topic aims to identify - and explore the actions of - mucosal barrier disruptors from original allergen sources. Preferred article types are Original Research and Reviews (Systematic Review, Review, Mini Review), but other article types, such as Methods, Perspective, Data Report, Brief Research Report, General Commentary and Opinion manuscripts will also be reviewed.
Here we invite all researchers working on individual allergen sources to present their research or literature reviews on the topics presented below. In addition, all the data pinpointing individual molecules as mucosal barrier modifying agents are welcomed and this includes both protein and non-protein molecules.
- Barrier disruptors from house dust mites
- Barrier disruptors from food allergen sources
- Barrier disruptors from fruit
- Barrier disruptors from weed pollen
- Barrier disruptors from grass pollen
- Barrier disruptors from tree pollen
- Animal models for monitoring epithelial barrier integrity
- In vitro tests for monitoring epithelial barrier integrity
Keywords: Allergens, mucosal barrier, surfactants, proteases, animal models, in vitro models, ex vivo models
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
