About this Research Topic
Immunoglobulin Y (IgY) is central to our understanding of immunoglobulin evolution across species. It has links to antibodies from the ancestral IgM to the mucosal IgX and IgA, as well as to mammalian serum IgG and IgE. The generation of IgY antibodies from hen egg yolk has been considered a good example of practicing the animal welfare 3R principle. The methodology for developing functional IgY fragments or chimeric antibodies is quite mature now. Interests in IgY technology span many areas of scientific research from basic immunology & biology to applications for both human & animal welfare.
Until now, the number of articles, patents, clinical studies, and commercial products on IgY technology has increased significantly and IgY technology is expected to continue its development in combination with the rapid advancements of modern biotechnology and biomedicine. A cross-disciplinary approach may enhance our understanding of IgY and promote IgY study and application.
In this Research Topic we welcome the submission of Original Research, Reviews, and Mini-Reviews articles, which cover, but are not limited to, the following topics:
• Understanding of immunoglobulins across species, as well as the evolution of immunoglobulins, with the emphasis on the IgY molecule;
• Biology and molecular structure of IgY, which cover IgY genetics and transformation, generation of IgY diversity, IgY domains, glycosylation, IgY variations, etc.;
• Technique aspects of IgY technology, including animal immunization, IgY extraction, and purification, antibody monitoring and evaluation, IgY delivery, as well as the integration of state of art biotechnology and pharmaceutical sciences to IgY technology;
• Generation of functional IgY fragments and chimeric antibody and antibody mimetics;
• Application of IgY technology in human and veterinary medicine, food sciences, immunoassay, and other aspects.
Until now, the number of articles, patents, clinical studies, and commercial products on IgY technology has increased significantly and IgY technology is expected to continue its development in combination with the rapid advancements of modern biotechnology and biomedicine. A cross-disciplinary approach may enhance our understanding of IgY and promote IgY study and application.
In this Research Topic we welcome the submission of Original Research, Reviews, and Mini-Reviews articles, which cover, but are not limited to, the following topics:
• Understanding of immunoglobulins across species, as well as the evolution of immunoglobulins, with the emphasis on the IgY molecule;
• Biology and molecular structure of IgY, which cover IgY genetics and transformation, generation of IgY diversity, IgY domains, glycosylation, IgY variations, etc.;
• Technique aspects of IgY technology, including animal immunization, IgY extraction, and purification, antibody monitoring and evaluation, IgY delivery, as well as the integration of state of art biotechnology and pharmaceutical sciences to IgY technology;
• Generation of functional IgY fragments and chimeric antibody and antibody mimetics;
• Application of IgY technology in human and veterinary medicine, food sciences, immunoassay, and other aspects.
Keywords: immunoglobulin Y, IgY, IgY technology, egg yolk antibody, antibody evolution, IgY product
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
