About this Research Topic
We aim to gain insights into the complex cellular mechanisms of aging-related diseases. Apart from Cdkn2a and Cdkn1a, tissue-specific markers of aging are various but remain to be characterized and studied in more detail. The manifold possibilities of Next-Generation Sequencing (NGS), applied to the aging field, will allow us to specifically unveil new mechanisms and – potentially – targets to attack pathways involved in tissue-specific age-related decline. We explicitly aim to learn about these cell-specific processes and signaling cascades in seemingly disconnected issues and diseases. Cancer and neurodegenerative diseases will give us new insights and ideas as well as concepts with broad applicability across organs and disciplines.
This Research Topic welcomes manuscripts on next-generation sequencing of aging-related diseases. In particular, the Topic Editors welcome manuscripts on Single-Cell-Sequencing (scSeq) and Cytometry by time of flight (CyTOF) and Bulk RNA-Seq in
- Osteoarthritis, Osteoporosis
- Osteosarcoma, Colorectal Carcinoma, Hepatocellular Carcinoma
- Alzheimer’s Disease, Vascular Dementia, Parkinson's Disease Dementia, Huntington's Disease.
- Type 2 diabetes, Hypertension
- Atherosclerosis, Cardiovascular diseases
Keywords: Next generation sequencing, NGS, aging, cancer, osteoporosis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.