Aging is affecting all organs and tissues of most mammals. It is currently known that certain cancers are aging-related, and various diseases show a clear age dependence. In the bone field, osteoporosis is a disease mostly of the aged population, and cellular senescence has been linked to a steady decline in bone mass and density. With the uprise of Next-Generation-Sequencing (NGS), in particular single cell-based technologies, it is now possible to dissect and identify specific cells and cell types that are the putative drivers of these developments. Whether these are osteocytes or osteoblasts of the skeleton to drive osteoporosis or fibro-adipogenic progenitors in skeletal muscle to promote muscle wasting, or epithelial cells in the colon to initiate a cancerous devolution – with single cells becoming the focus of attention, these cells can be examined in detail on both a transcriptomic and proteomic level. We aim to decipher the cellular proportions and functional contributions and identify the cell populations and mechanisms that are causal for various aging-related diseases.

We aim to gain insights into the complex cellular mechanisms of aging-related diseases. Apart from Cdkn2a and Cdkn1a, tissue-specific markers of aging are various but remain to be characterized and studied in more detail. The manifold possibilities of Next-Generation Sequencing (NGS), applied to the aging field, will allow us to specifically unveil new mechanisms and – potentially – targets to attack pathways involved in tissue-specific age-related decline. We explicitly aim to learn about these cell-specific processes and signaling cascades in seemingly disconnected issues and diseases. Cancer and neurodegenerative diseases will give us new insights and ideas as well as concepts with broad applicability across organs and disciplines.

This Research Topic welcomes manuscripts on next-generation sequencing of aging-related diseases. In particular, the Topic Editors welcome manuscripts on Single-Cell-Sequencing (scSeq) and Cytometry by time of flight (CyTOF) and Bulk RNA-Seq in

- Osteoarthritis, Osteoporosis

- Osteosarcoma, Colorectal Carcinoma, Hepatocellular Carcinoma

- Alzheimer’s Disease, Vascular Dementia, Parkinson's Disease Dementia, Huntington's Disease.

- Type 2 diabetes, Hypertension

- Atherosclerosis, Cardiovascular diseases

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