About this Research Topic
The role and regulation of cerebrospinal fluid (CSF) homeostasis has long eluded our understanding of normal and diseased brain states. However, recent work has begun to illuminate how the CSF regulates the brain and brain diseases (and vice versa) in ways that extend far beyond its passive historical roles. New approaches to study CSF biology have illuminated potential strategies for analysis, diagnosis and treatment of neurologic disorders. We hope to bring together an interdisciplinary group of scientists and clinicians to discuss the current state and future of CSF biology. Articles for this Special Issue should focus on discoveries about CSF tissues (choroid plexus), paths (glymphatics and lymphatics) and disease states related to abnormal neurodevelopment (i.e. hydrocephalus). Articles pertaining the mechanisms, genetics, and treatment of neurodevelopmental CSF-related disorders will be considered. Our goal is to critically appraise our understanding of CSF biology in both normal and diseased states and provide an avenue for biologists and clinicians interested in CSF disorders to showcase their work.
Keywords: Cerebrospinal fluid, Hydrocephalus, Neurodevelopment, Neural stem cell, Neonatal hemorrhage, Neonatal infection
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