This Research Topic is Volume II of a series. The previous volume, which has attracted over 16,000 views can be found here: The Hierarchical Organization of Supramolecular Systems: From Fundamentals to Biomedical Applications.

Supramolecular systems are inherently hierarchical in their organization: non-covalent interactions encoded by the structure of molecular building blocks lead to the ordering on a length scale. The emergence of supramolecular studies has inspired a wave of restructuring toward an intensive interdisciplinary field integrating the fundamentals underlying physics, chemistry, biology, as well as materials and resulted in a variety of outputs. One of the most booming outputs is the application of supramolecular materials in the field of biomedicine and biotechnology, attracting increasing attention to accumulate new knowledge and develop novel technologies for creating the next generation of materials used in disease diagnosis and treatment, biomechanics, etc.

This Research Topic seeks to showcase publications dealing with the design, development, and biological applications of supramolecular structures. We welcome Original Research articles as well as Review articles with new findings related to the structures, properties, and biomedical applications of supramolecular systems. We also welcome papers that lay a profound theoretical understanding of the intermolecular interactions and modulation mechanism of the sophisticated supramolecular architectures formed by the astronomical number of molecular assemblies. We aim to provide researchers with a forum to present work at the forefront of supramolecular science while stimulating the development of exciting multidisciplinary and pioneering research. Through the Frontiers innovative peer review system and open access model, we strive to be the go-to research resource for researchers in the field of supramolecular science and self-assembly.

This Research Topic is looking to promote the area by publishing groundbreaking results from established and emerging areas. Topics include but are not limited to:

- The supramolecular structures of biology-relevant systems
- Biology-inspired assemblies
- Biology-derived molecular assemblies
- Host-guest systems and host-guest interactions
- Supramolecular polymers and antimicrobial materials
- Molecular machines and motors
- Modulating the biological effects of supramolecular systems
- Molecular sensors (chemosensors and biosensors)
- Supramolecular catalysts
- Self-assembly and directed-assembly
- DNA origami and DNA nanotechnology
- Biological supramolecular system
- Supramolecular assembly at surfaces
- Supramolecular composites
- Developments in theoretical and practical aspects of supramolecular science

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