“A year in review: Discussions in Antigen Presenting Cell Biology” is part of a wider series of Research Topics across Frontiers in Immunology, hosted by our Speciality Chief Editors.

This Research Topic aims to spark discussion around popular spontaneous articles from 2021 in Antigen Presenting Cell Biology. The Antigen Presenting Cell Biology field is continuously evolving, therefore we are seeking to understand developments and perspectives on articles that have attracted attention throughout the year.

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The chosen manuscripts are :

Unraveling the Heterogeneity and Ontogeny of Dendritic Cells Using Single-Cell RNA Sequencing

A New Human Leukocyte Antigen Typing Algorithm Combined With Currently Available Genotyping Tools Based on Next-Generation Sequencing Data and Guidelines to Select the Most Likely Human Leukocyte Antigen Genotype

Macrophages Control the Bioavailability of Vitamin D and Vitamin D-Regulated T Cell Responses

Mutation in Irf8 Gene (Irf8R294C) Impairs Type I IFN-Mediated Antiviral Immune Response by Murine pDCs

Congenital Deficiency of Conventional Dendritic Cells Promotes the Development of Atopic Dermatitis-Like Inflammation

An IRF1-IRF4 Toggle-Switch Controls Tolerogenic and Immunogenic Transcriptional Programming in Human Langerhans Cells

ERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29

Macrophage Polarization and Its Role in Liver Disease

Sepsis Inflammation Impairs the Generation of Functional Dendritic Cells by Targeting Their Progenitors

The Ontogeny and Function of Placental Macrophages

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This topic will be summarized by the specialty chief editors in an editorial alongside their vision for Antigen Presenting Cell Biology.

We welcome Opinions, Perspectives, Hypotheses and Theory, and Mini-Review article types to facilitate this discussion. Please note only papers that are relevant and add a significant contribution to the discussion articles will be considered.

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