About this Research Topic
Heterodienes are among the most widely used intermediates in organic synthesis due to their synthetic availability and versatile reactivity. The presence of an electronegative heteroatom(s) in a conjugated system of pi-bonds leads to an enhanced reactivity towards nucleophiles, carbenoids and free radicals. Being A4-synthons, heterodienes are ideal building blocks to construct heterocyclic rings via [4+2]-, [4+1]-, [4+3]-cycloaddition/annulation processes. Finally, heterodienes are compatible with various types of organo- and metallocatalysts allowing the asymmetric synthesis of target products, in particular natural and pharmaceutically relevant compounds. Enantioselective Michael addition, cycloaddition and cascade reactions with stable heterodienes (e.g. alpha,β-unsaturated carbonyl compounds and nitroalkenes) have been successfully developed in the recent years. However, the use of labile heterodienes (e.g. azadienes, conjugated nitroso- and azoalkenes) in these transformations is still underdeveloped. Thus, the chemistry of heterodienes is an extensively developing field with a number of challenges.
The aim of the current Research Topic is to cover cutting edge research and emerging trends in heterodiene chemistry. A specific focus will be put on new applications of heterodienes in the synthesis of products relevant to medicinal chemistry. Overall, we believe that this collection of articles will not only represent the current state-of-art in the field of heterodienes, but also will outline the remaining challenges and stimulate further research.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• New transformations of heterodienes (alpha,β-unsaturated carbonyl compounds, azadienes, nitro-, nitroso- and azoalkenes, etc.)
• Asymmetric catalytic transformations of heterodienes
• Application of heterodienes in the synthesis of natural products and pharmaceutically relevant molecules
• Theoretical insights into the structure and reactivity of heterodienes
• Heterodienes in materials science
The aim of the current Research Topic is to cover cutting edge research and emerging trends in heterodiene chemistry. A specific focus will be put on new applications of heterodienes in the synthesis of products relevant to medicinal chemistry. Overall, we believe that this collection of articles will not only represent the current state-of-art in the field of heterodienes, but also will outline the remaining challenges and stimulate further research.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• New transformations of heterodienes (alpha,β-unsaturated carbonyl compounds, azadienes, nitro-, nitroso- and azoalkenes, etc.)
• Asymmetric catalytic transformations of heterodienes
• Application of heterodienes in the synthesis of natural products and pharmaceutically relevant molecules
• Theoretical insights into the structure and reactivity of heterodienes
• Heterodienes in materials science
Keywords: Heterodienes, Michael addition, Organocatalysis, Cycloadditions, Cascade reactions, Medicinal chemistry
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
