About this Research Topic
The artificial intestine models can recreate the complex processes that occur in the human intestine, including the secretion of digestive enzymes and the absorption of nutrients. They allow researchers to better understand the impact of factors such as diet, drugs, and disease on the intestinal environment.
Organ-on-chip models, on the other hand, offer a more advanced and integrated method of studying organ function by mimicking the interactions between different organs and their respective systems. These models can be designed to include multiple organs, including the intestine, liver, pancreas, and others, to simulate the interplay between these organs and their impact on nutrient metabolism.
These models provide a more controlled and sophisticated method of studying nutrient metabolism and absorption, giving valuable insights into the complex processes of the human body and aiding in the development of new treatments and therapies. Furthermore, the modeling approach helps researchers overcome experimental design limitations and ethical restrictions commonly associated with animal studies.
This Research Topic "Can we model it?" aims to shed light on the role of intestinal models in nutrient science, exploring questions such as the use of nutrient conversion and adsorption models in clinical research, and the adequacy of organ-on-chip models for organism-level studies. This topic encourages the submission of original studies that utilize artificial intestine simulators, organ-on-chip, and in silico models, as well as studies comparing and validating nutrient adsorption models based on host cell lines and tissues and models incorporating the host's microbiota.
Keywords: organ-on-chip, nutrition, methodology, intestine, model, modelling, nutrient adsorption, gut microbiota, artificial intestine, simulators
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