This Research Topic is part of a series with Streaming Inflammation: From Damage to Healing and Resilience - Volume I:

The primary challenge of 2021 is to continue to heal from the systemic damages incurred over a lifetime, while appreciating the scientific challenges and opportunities presented by the COVID pandemic. Inflammation is normally a sign of a good maintenance system. It occurs at different stages in different scenarios all over the body at the same time and often unnoticed. How is the stream of molecular and cellular players coordinated in a systemic response that dynamically maintains integrity of the whole?

Our goal is to spotlight inflammation in three dynamic relationships of health and disease: damage, healing and resilience. Detailed charts depict mechanisms that elicit local inflammation. Little is known about how these basic housekeeping systems are modulated in context of an organism that is simultaneously and chronically challenged by pathogens, environmental stimuli, metabolic drugs, microbiome and diet. The focus is on responsiveness in contexts of inherited disorders, chronic inflammatory diseases, environmental stimuli, host defense, diet and therapy.

Our aim is to create a novel landscape of recovery from inflammation under chronic systemic conditions. We encourage open communication of ideas and invite researchers from different fields of expertise to submit Original Research, Hypothesis and Theory, Perspective, Clinical Trials, Case Reports, Brief Research Reports, Mini Reviews, Systematic Reviews, Opinion Articles, Methods and Technology of Code articles. We welcome submissions interrogating, but not limited to, the following questions:

• Which molecular and cellular mechanisms adapt to maintain homeostasis?
• What are the surrogate markers, and can we measure them?
• Which mediators facilitate tissue-specific responses and systemic challenges?
• Is there a panacea?
• How does each individual’s genetics impact variation in personal response to drug and diet intervention?

Eric E. Schadt is the CEO and founder of SEMA4.
The other Topic Editors have no competing interests related to this Research Topic to declare.

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