About this Research Topic
Five-membered heterocycles are among the broadest class of organic compounds. Major sub-classes of these compounds are imidazole, isoxazole, pyrazole, oxazole, tetrazole, thiazole, triazole, and other aliphatic heterocycles as cornerstones of several drugs and bioactive compounds. Isoxazole, imidazole, and thiazole moieties are ubiquitous as natural products. Pyrazole nucleus is rarely found as natural products, and triazole and tetrazole derivatives are purely synthetic compounds. Some of the most widely used drugs such as Dasatinib, Rimonabant, etc. contain these heterocycles as their core structures. These structures also found in widely used insecticides and herbicides. Five-membered heterocycles are also gaining attention over the years as smart-materials.
Novel methodologies to synthesize substituted five-membered heterocycles, functionalization of commercially or readily available core structures, and pharmaceutical and material studies of these compounds are still underexplored areas of organic chemistry. Novel synthetic methods and functionalization including domino protocol and green chemistry approaches will help to address the synthesis of new five-membered heterocycles. Biological and material studies of these novel compounds will help to address the application part of the problem. This thematic issue will be focused on the organic synthesis, derivatization of known compounds, medicinal chemistry, and material applications of novel five-membered heterocycles. Critical review of existing literature will also address this issue.
The aim of this thematic issue is to publish topics covering novel research frontiers of five-membered heterocycles. The topic editors encourage submissions of Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• The development of novel methodologies for the synthesis of new compounds or therapeutically active molecules.
• Synthesis and biological and material application of five-membered heterocycles.
• Computational studies supported by experimental evidence.
Novel methodologies to synthesize substituted five-membered heterocycles, functionalization of commercially or readily available core structures, and pharmaceutical and material studies of these compounds are still underexplored areas of organic chemistry. Novel synthetic methods and functionalization including domino protocol and green chemistry approaches will help to address the synthesis of new five-membered heterocycles. Biological and material studies of these novel compounds will help to address the application part of the problem. This thematic issue will be focused on the organic synthesis, derivatization of known compounds, medicinal chemistry, and material applications of novel five-membered heterocycles. Critical review of existing literature will also address this issue.
The aim of this thematic issue is to publish topics covering novel research frontiers of five-membered heterocycles. The topic editors encourage submissions of Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• The development of novel methodologies for the synthesis of new compounds or therapeutically active molecules.
• Synthesis and biological and material application of five-membered heterocycles.
• Computational studies supported by experimental evidence.
Keywords: Pyrazole, Thiazole, Oxazole, Pyrrole, Furan, Thiophene, Imidazole, Triazole, Tetrazole, Aliphatic five-membered heterocycles
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
