About this Research Topic
Currently, there are several issues about PRN therapy remain unsolved: (1) the low bioavailability and high-dose usage of PRN therapy in IH; (2) the potential long-term side effects of PRN in children; (3) resistance to PRN therapy in IH. To solve the above issue, many efforts have been made, including: (1) novel drug delivery technology to improve the bioavailability of PRN; (2) the application of alternative methods to PRN treatment; (3) advances in targeted therapies based on the deep understanding of the pathogenesis of IH. Nevertheless, future clinical trials and basic studies are needed to provide support to the above findings.
Therefore, for this Research Topic, we invite authors to submit Original Research, Reviews, and Clinical Trials that provide novel findings in the field of therapeutic approaches targeting IH. Topics of interest include:
• Clinical trials about beta-blocker therapy for IH
• Emerging drug therapies for IH
• Propranolol resistance and its molecular mechanism
• Effective drug delivery methods for IH
• Targeted therapy for IH
• Clinical findings about refractory IH
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: Infantile hemangioma, beta-blocker, propranolol, medical management, angiogenesis/vasculogenesis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.