About this Research Topic
Nanomaterials have emerged as a promising field that holds enormous potential in bone tissue engineering. The use of such nanoscale particles for the delivery of drugs and the fabrication of scaffolds has promoted bone tissue regeneration. The various properties of nanoparticles are primarily governed by their chemical configuration, chemical activity, chemical composition, and topography, affecting the results of cell growth, osteogenesis, and angiogenesis. Due to the large surface area to volume ratio, these advanced nanomaterials hold great potential for targeted drug delivery, biomimetics design, stem cell recruitment, molecules, and cellular uptake. Recently, the applications of nano-phase ceramics, carbon nanomaterials, titanium nanomaterials, nano-structured polymers, metal nanoparticles, nanoscale metal-organic framework, and polypeptide nano bone frameworks have already been reported.
Significant bone defects are still a challenge to reconstructive surgery, and many approaches are being used to generate the simulated bone microenvironment. Stem cells have received much attention due to great promises in bone regeneration. Criteria for multiple types of stem cells include their ability to self-renew and retain their ability to differentiate in response to specific microenvironments upon bone repairing. Based on these characteristics, the applications of stem cell-based/ targeted bone tissue engineering have been recently investigated. Advanced nanomaterials offer attractive solutions to engineer functional stem cell niches and enhance stem cell recruitment. The chemical characteristics of nanomaterials affect stem cells, which in turn mediate complex chemical reactions in biological microenvironments. In addition, the potential stem cell resources for bone tissue engineering are diverse, including bone marrow-derived stem cells, adipose-derived stem cells, dental tissue-derived stem cells, and induced pluripotent stem cells.
We welcome submissions of Original Research, Review, Mini-Review articles focusing on but not limited to the following subtopics:
• Applications of nanomaterials in bone tissue engineering
• Nanomaterial-assisted drug delivery strategies for bone tissue regeneration
• Nanomaterial-assisted biomimetics strategies for bone tissue regeneration
• Nanomaterial-based implant surface modification for osseointegration enhancement
• Regenerative medicine and stem cell-based bone tissue engineering
• Engineering stem cell niches for bone tissue regeneration
• Stem cell-targeted nanomaterial with future applications in bone tissue engineering
Significant bone defects are still a challenge to reconstructive surgery, and many approaches are being used to generate the simulated bone microenvironment. Stem cells have received much attention due to great promises in bone regeneration. Criteria for multiple types of stem cells include their ability to self-renew and retain their ability to differentiate in response to specific microenvironments upon bone repairing. Based on these characteristics, the applications of stem cell-based/ targeted bone tissue engineering have been recently investigated. Advanced nanomaterials offer attractive solutions to engineer functional stem cell niches and enhance stem cell recruitment. The chemical characteristics of nanomaterials affect stem cells, which in turn mediate complex chemical reactions in biological microenvironments. In addition, the potential stem cell resources for bone tissue engineering are diverse, including bone marrow-derived stem cells, adipose-derived stem cells, dental tissue-derived stem cells, and induced pluripotent stem cells.
We welcome submissions of Original Research, Review, Mini-Review articles focusing on but not limited to the following subtopics:
• Applications of nanomaterials in bone tissue engineering
• Nanomaterial-assisted drug delivery strategies for bone tissue regeneration
• Nanomaterial-assisted biomimetics strategies for bone tissue regeneration
• Nanomaterial-based implant surface modification for osseointegration enhancement
• Regenerative medicine and stem cell-based bone tissue engineering
• Engineering stem cell niches for bone tissue regeneration
• Stem cell-targeted nanomaterial with future applications in bone tissue engineering
Keywords: Nanomaterials, Bone tissue engineering, Stem cells, Drug delivery, Implant
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
