About this Research Topic
The purpose of this Research Topic is to collect studies that can contribute to understand the mechanisms by which prions and prion-like proteins are involved in the onset of neurodegenerative diseases. New data on different aspects of prion-like proteins such as protein structure, misfolding process, aggregation and precipitation mechanisms, cytotoxic effect and pathological effect at the nervous system level are required for a broader understanding of the pathophysiological mechanisms causing the onset of neurodegenerative disorders with a strong social impact. New information can contribute to the identification of new cellular mechanisms and to define new cellular and organismic models useful for the study of prion and prion-like proteins.
This Research Topic calls for original articles, reviews, and perspectives in relevant research fields on prion and prion-like proteins, including molecular evolution and structure variation in vertebrates, protein misfolding, precipitation and aggregation mechanism, cytotoxicity of prion-like protein aggregates and pathological effect on the nervous system.
Dr. Simona Eleuteri holds a patent (pharmacological chaperone to stabilize retromer complex in the CNS, EP19166534.8) with San Raffaele Hospital and has collaborations with Neuropore Therapies Company and Nestlè Company.
Keywords: Prion, Prion-like, Synuclein, PrPsc, Alzheimer's disease, Tau protein, Parkinson's disease, Multiple System Atrophy, Amyotrophic lateral sclerosis
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