The Covid-19 pandemic brought on by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has presented numerous clinical challenges and a range of outcomes since it began. As the pandemic progresses, more information has come to light about the effect of SARS-CoV-2 and Covid-19 on a variety of physiological systems and illnesses, such as those of the endocrine system and those relating to the adrenal and pituitary glands.

SARS-CoV-2 enters host cells by first attaching to angiotensin-converting enzyme 2 (ACE2). ACE2 is expressed on tissue throughout the body, in the lungs, kidneys, gastrointestinal tract, and the adrenal and pituitary glands. Evidence suggests this is a possible connection point for Covid-19 to affect the hypothalamic-pituitary-adrenal (HPA) axis along with the expression of numerous pituitary and endocrine disorders. Observations of comorbidities and clinical outcomes such as altered growth hormone levels and disturbance of the HPA axis have been noted in Covid-19 cases around the world, but the exact connection to the disease remains unexplored.

This Research Topic will compile research relating to the relationship between Covid-19 and various aspects of pituitary endocrinology. Research discussing pituitary disorders (E.g., Cushing’s Syndrome and Disease, adrenal insufficiency, acromegaly, etc.), reduced or altered pituitary and adrenal gland functionality, and related topics are particularly encouraged. We welcome original research, review, mini review, systematic review, and perspective manuscripts.

*For articles relating to other aspects of Covid-19 and endocrine research, please see our related Research Topics
Endocrinology and COVID-19: A Cross-Disciplinary Topic Vol. 2
Endocrinology and COVID-19: A Cross-Disciplinary Topic
Covid-19 and Diabetes Volume II
Covid-19 and Diabetes
Long COVID and Diabetes
Covid-19 and Obesity
The Thyroid and Covid-19
New Drugs for treating COVID-19 Cancer Patients
Musculoskeletal Diseases in COVID-19 Epidemic-19
Endocrine Consequences in Children Due to the COVID-19 Pandemic Social Behavior Changes

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