Male cancers, such as prostate cancer, male breast cancer, testicular cancer, etc., have become one of the major health issues worldwide. Except for Prostate cancer, most of the other male specific cancers are less studied compared to the female specific counterparts. More recent reports suggest male specific cancers carry characteristic changes in the genome due to the sex differences. This research topic is therefore intended to reveal the important and unique mechanisms in poorly studied male specific cancers (such as prostate cancer, male breast cancer, testicular cancer, etc.) which influence oncogenesis, cancer invasiveness, responses as well as the outcomes. Through these mechanisms, we will be able to identify drivers or mediators of these rare yet unique cancers.

The goal of this research topic is to uncover the breaking and unique changes on the level of genome and epigenome which play a role in the bio-pathological processes underlying male specific cancer development. Such discoveries will inform the oncological society with new candidates of male-specific cancer mutations and genes and with functional implications. This will subsequently provide additional evidence for accurate clinical predictions and informed management of male-specific cancers, including future precision medicines while revealing unique sex-related/sex-hormone-related mechanisms of these cancers. The special issue will mainly focus on the unique genetic and epigenetic alterations of male cancers and thereby improving our knowledge of male specific cancers.

For this special issue, our research topic will mainly focus on the roles of genome and epigenome poorly studied male cancers including but not limited to;
- Prostate cancer
- Male breast cancer
- Testicular cancer
- Penile cancer

Studies including basic research, translational research, and clinical research are welcomed. We accept “original research”, “systematic reviews”, “reviews”, “clinical trial”, and “brief research report”. Other types of manuscript will be evaluated by the editors before further consideration.

Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.

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