The morbidity and mortality rates of gastrointestinal cancers remain high all over the world. Different mechanisms are involved in the development and progression of cancer. Tumor Microenvironment (TME) includes immune cells, fibroblasts, lymphocytes, and other components that affect the progression of cancer. Alterations in the components of TME largely influence gastrointestinal tumor metastasis and contribute to adverse patient prognosis. As the human transcriptome is intensively investigated, an increasing number of non-coding RNAs (nc-RNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have been shown to engage in tumor microenvironment-mediated tumorigenesis, angiogenesis, invasion, metastasis and chemoresistance. It is promising to elucidate the regulatory relationship between ncRNA and TME to help develop new therapeutic strategies for gastrointestinal tumor, which is extremely beneficial to improve the survival prognosis of tumor patients. The composition of TME is complex, and a variety of nc-RNAs are known to play a role in TME, but more research is needed to investigate the specific regulatory roles. Moreover, how the aberrant expression of nc-RNAs in TME is regulated is also an urgent question to be investigated. Therefore, we are committed to finding the significant regulatory roles of nc-RNAs in various components of TME and providing an essential theoretical basis for their application in tumor diagnosis as well as therapy.

We welcome authors to submit Original Research and Review articles contributing to better understanding of the intricate networks of TME and ncRNAs interactions in the gastrointestinal tumor that modulate tumor growth, metastasis, immune escape mechanism and drug resistance.

Potential topics can include, but are not limited to:
• NcRNAs in TME that are involved in tumorigenesis, invasion, metastasis;
• Interactions between TME and ncRNAs leading to immune escape mechanisms and therapy resistance；
• Mechanisms of TME affecting tumor metastasis;
• Metabolic reprogramming regulated by ncRNAs in TME；
• Development of ncRNAs-based therapeutics;
• Discovery of new ncRNAs that can be used as tumor metastasis markers.

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Frontiers in Cell and Developmental Biology

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