The onset and early growth of primary epithelial malignancies are associated with excessive epithelial cell proliferation and angiogenesis. In aberrant circumstances, epithelial to mesenchymal transition (EMT) occurs during the normal physiological tissue repair process, leading to angiogenesis, fibrosis, loss of function, and carcinoma. The initiation of an EMT mechanism has been hypothesized as a crucial pathway for epithelial cancer cells to acquire malignant phenotypes. SIRT1, p38 MAPK, NFAT1, SMAD, IL-6, STAT3, AQP5, notch 1, PI3K/Akt, Wnt/-catenin, NF-B, FAK/AKT, and Hh are some of the signaling pathways that govern the EMT process. Controlling the EMT process, which results in cancer, fibrosis, and inflammatory disorders, is a novel approach to cancer treatment. The EMT process is triggered by the overexpression of β-catenin. Targeting various cancer-related transcriptions, such as β-catenin, a key regulator of the Wnt signaling pathway, p90 ribosomal S6 kinase (RSK) of the Notch signaling pathway, PI3K/Akt pathway, and NF-B pathway, can have anticancer effects by inhibiting proliferation, angiogenesis, invasion, and metastasis. MiR-34a, an antiangiogenic factor, can be boosted by anticancer bioactives, resulting in decreased migration, angiogenesis, and cell survival.

Molecules such as Discodermolide and Bryostatins, which come from marine bioactive peptides, and Taxol, vinblastine, and camptothecin, which come from plant bioactive peptides, are just a few examples of compounds that have been discovered. Semisynthetic derivatives can be more effective, especially when combined with another pure compound.

This special issue encourage research and reviews that use in vitro, in vivo, and in silicon techniques to modulate/target tumors via EMT-related transduction signaling pathways by plant and marine bioactives or semi-synthetic compounds on various cancers.

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All the manuscripts submitted to the collection will need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here). In silico studies will not be accepted through Ethnopharmacology, so must be submitted to the topic through one of the other sections.

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