About this Research Topic
These insights into clot composition have been gathered using a plethora of in vitro and in vivo experimental systems modelling thrombus and fibrin formation combined with histological analyses of human thrombi collected by thrombectomy. Further, computational in silico modelling contribute progressively to our understanding of thrombus formation and build-up. Despite the great number of experimental tools and data available, the unexplained thrombotic complications seen in patients are still substantial. Hence, expanding our understanding of clot composition and structure in physiological and pathophysiological conditions will aid in the development and improvement of current and new antithrombotic treatments with limited hemorrhagic complications.
Topics may include, but are not limited to the assessment of:
1) Thrombus build-up and fibrin network structure.
2) Influence of genetic deficiency or acquired platelet or fibrin defects on clot properties.
3) The comparison and suitability of in vitro, in vivo and in silico research methods and novel advances within the field.
We welcome the submission of original articles, reviews, hypotheses/theory articles, method and protocol papers.
Keywords: Thrombus formation, clot structure, platelets, fibrin, microfluidics, in vivo thrombosis models, in silico modelling
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