About this Research Topic
Several complement inhibitors have been tested in kidney transplant recipients with mixed outcomes, depending on indication and disease severity. With the increased specificity of new agents targeting each step of complement cascade, there is a need to robustly examine the impact of these drugs in the context of transplantation.
We will review current and novel anti-complement strategies in the transplant setting, including deceased donor-directed therapies, prevention of delayed graft function and ischemia/reperfusion injury, and prevention of T-cell and antibody-mediated rejection, particularly in highly sensitized patients. We will also explore the effects of systemic and local complement synthesis and inhibition, long-term effects of complement inhibition on alloimmune compartments, and other therapeutic applications such as improvement of normothermic perfusion and reduction of innate activation in deceased donors.
Keywords: complement system, Organ transplantation, inhibitors
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.