The human body is a dynamic living system that can rapidly respond to the changes of pH, electric and magnetic field, heat, light, ionic strength, and chemical cues in the physiological environment. To obtain reliable results from biological testing, replicating the dynamic behaviors of tissues/organs is an indispensable factor for modeling biomimetic systems. Recently, stimuli-responsive biomaterials have attracted widespread attention as new type materials for designing environment-responsive systems because they enable the response to the changes in different signals from the environment. By regulating the external and internal stimuli ranging from triggers, stimuli-responsive biomaterials provide a new strategy to design versatile biomimetic systems. Therefore, the ability of stimuli-responsive biomaterials shows great promise of fabricating new-type constructs in precision medicine and benefit the translation medicine in biomedical applications.

During the past few decades, stimuli-responsive materials relying on biological, chemical, and physical cues have become a rapidly growing and enormously promising field. The main goal of this Research Topic is to collect high-quality research on stimuli-responsive biomaterials that are structurally or functionally similar to their biological equivalents for design smart biomimetic systems. Moreover, this Topic will emphasize recent advances in the application of stimuli-responsive biomaterials in the field of drug delivery, targeted therapy, tissue engineering, bioimaging, sensing, drug testing/drug repurposing, and organ-on-chips because of the continuous need to improve the quality of biomimetic systems for diagnosis and treatment in precision medicine, tissue engineering, and regenerative medicine.

The current Research Topic aims to cover promising, recent, and novel research trends and reviews in the applications of stimuli-responsive biomaterials. Areas to be covered in this Research Topic may include, but are not limited to:

Bioinspired, Biomedical, and Biomolecular Stimuli-responsive Materials, such as:
• Stimuli-Responsive Biomaterials for Artificial Tissues Fabrication and In vitro Biomimetic systems
• Adaptive and Self-shaping Biomaterials for Tissue Engineering, Cell/Stem cell, tissue, organoid culture
• Stimuli-Responsive Biomaterials for Self-healing, Self-cleaning, Controllable Friction, and Reversible Adhesion,
• Stimuli-responsive Biomaterials for Drug Delivery, Control Release, and Cancer therapy.
• Stimuli-responsive Biomaterials for Robotic Applications
• Stimuli-responsive Biomaterials for Cell Targeting, Biosensors, Bioimaging.

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Frontiers in Bioengineering and Biotechnology

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