The Editor's Feature emphasizes high-quality collections that have been developed in our journal each month. This Research Topic has been acknowledged by the Specialty Chief Editor of the Biomaterials section, Dr. Hasan Uludag, for its outstanding contribution to the field, focus on a timely theme, and its team of excellent Topic Editors who are collaborating with us.

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Biocompatible and biodegradable polymers are an attractive choice for the development of MSDs tissue regeneration. In recent years, dopamine, a hormone and neurotransmitter in the human body, has been developed for biological usage. Spontaneous oxidative polymerization of dopamine provides an inspired material based on adhesive proteins in mussels containing catecholamine groups. This melanin-like material has expanded in typical applications such as surface coating, drug delivery, and tissue engineering due to biocompatibility, bioactivity, hydrophilicity, bio-adhesion, thermal stability, and functionalization capability with other materials. Accordingly, this Research Topic aims to highlight the sign of progress in biofabrication of polydopamine-based structures as well as surface engineering strategies to develop a new generation of therapeutic methods for MSD repair and restoration of function.

The scope of this Research Topic will highlight the innovative therapeutic methods based on polydopamine for musculoskeletal tissue regeneration using new material formulation, novel structural design, and surface engineering strategies. Types of manuscripts to be featured mainly include Original Research (full paper and letter) and Perspective articles. Review articles that describe the current state-of-the-art in polydopamine development for tissue regeneration are welcomed. Within this view, this Research Topic encourage submissions addressing, but are not limited to, the following:

- Disease modeling as well as related molecular genetics, pathophysiology, and epidemiology
- Formulation of novel composition based on polydopamine for regeneration of MSD defects
- Design and development of polydopamine-based constructs for MSD tissue repair
- Introduction of new methodology for fabrication of polydopamine-based nanostructures using experimental or theoretical approaches
- Development of surface engineering strategies based on polydopamine for MSD tissue applications

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