About this Research Topic

Background

Coronavirus disease 2019 (COVID-19), produces the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with atypical pneumonia. This infection is a global health challenge producing post-acute sequelae of SARS-CoV-2 infection (PASC), including neuro-PASC in which direct or indirect invasion of the virus into the brain causes immune dysregulation, hormonal disorders, elevated cytokine levels due to immune reaction and chronic inflammation, direct tissue injury, and persistent low-grade infection.

The COVID-19 induced-neuroinflammation promotes blood-brain barrier (BBB) disruption, access of antigens and inflammatory factors into the brain, as well as infection or immune-mediated response in the neuromuscular system. It is therefore necessary to explore whether there is a close correlation with the adenosine pathway, the activation of the ACE receptor by the virus, the concentration of IL6 and the neuro-invasive effect of COVID-19. Other points of interest are the analysis of the autonomic dysfunction induced by cytokines; the effect of vaccine mRNA delivery in Central and Peripheral Nervous System, the long-term effects of Covid 19 infection and/or therapeutic approach in different pandemic countries. In this Research Topic we aim to including submissions and research from different countries, which will allow comparisons of loco-regional clinical experiences, diagnostic flow-charts, and different therapeutic approaches.

therefore, for this Research Topic we welcome submissions of Original Research, Case Reports, Reviews, and Meta-Analyses on, but not limited to:

-Neurological disorders of post covid-19 -infection in different pandemic countries;

-Neurological aspects of sudden death in COVID 19 -infection in different pandemic countries.

Visit Volume II of this Research Topic.

Keywords: SARS-CoV-2, PASC, neuro-PASC, neuroinflammation

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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