Tissue engineering and regenerative medicine, via combining multidisciplinary sciences, including materials, engineering, biology, chemistry, and physics, aim to generate tissues and organs substitute for biomedical applications. Due to the excellent biocompatibility, low toxicity, immune reactivity, and low bacterial adherence, the protein, including collagen, gelatin, keratin, silk, and fibrin, has been developed as scaffolds/hydrogels/bio-ink for tissue engineering, such as, for 3D bioprinting because of protein-based biomaterials depending on shear force, temperature, pH, polyols, etc. However, the design, preparation, and evaluation of protein-based biomaterials for tissue engineering still needs to be further enhanced to mimic complex geometries, such as hierarchical structure or gradient structure, and the biological characterization in vitro and in vivo needs to be performed. Thus, the excellent development of protein-based biomaterials will be a guarantee for their future clinical application.

The goal of this Research Topic is to publish papers including research articles, short communications, review articles, and opinions covering the latest studies and progress on protein-based biomaterials, including hydrogels, scaffolds, bio-inks, and so on, for biomedical applications. This Research Topic aims to become the reference relevant to the design, preparation, printability evaluation of protein-based biomaterials for tissue engineering applications.

The main scope of this research topic includes new concepts in the design and preparation of protein-based hydrogels and protein-based scaffold, protein-based bio-inks, in vitro and in vivo evaluation, specific biomedical applications. We welcome submissions in the following themes, but not limited to:

(1) Design, preparation, and characterization of protein-based biomaterials.

(2) Printability evaluation of protein-based bio-ink for 3D bioprinting.

(3) Cell proliferation and differentiation in protein-based biomaterials.

(4) Hierarchical structure protein-based biomaterials.

(5) Gradient structure protein-based biomaterials.

(6) Collagen-based biomaterials.

(7) Gelatin-based biomaterials.

(8) Keratin-based biomaterials.

(9) Silk fibrin-based biomaterials.

(10) Protein-based biomaterials via 3D bioprinting for specific medical applications.

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Frontiers in Bioengineering and Biotechnology

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