About this Research Topic
Organelle can play their own functions and form a network of organelle interactions(such as mitochondria-lysosome, mitochondria-lipid droplets, lysosome-autophagosome, etc.) to participate in cellular functions cellular homeostasis in various diseases such as cancer, osteoarthritis, non-alcoholic fatty liver and neurodegenerative diseases. Drug development using organelle(such as mitochondria) as targets has become a hot research topic. It is the direction of drug development such as anti-tumor anti-depressant and anti-ageing. Increasingly works proved that mitochondria provide the vast majority of adenosine triphosphate via the oxidative phosphorylation system and function gatekeepers for apoptosis and inflammation and as storage compartments for metabolites (e.g., calcium, lipids, and protons) to participate in the occurrence of tumors using various detection tools.
Newly developed technologies such as super-resolution imaging, such as stimulated emission depletion (STED), structured illumination microscopy (SIM), and stochastic optical reconstruction microscopy (STORM), as well as other single-molecule super-resolution imaging techniques, are enhanced new tools for investigating the dynamics of subcellular structures, including mitochondria. Combining functional fluorescent probes, optogenetics, and photodynamic therapy with super-resolution imaging is an excellent strategy for clarifying the underlying pathology for organelle associated drugs such as small molecular (functional inhibitors, natural active products, etc.) and macromolecules (peptides, proteins, antibodies, glycans, nucleic acids, etc.).
To achieve antitumor effects, drugs can induce organelle responses such as mitochondrial (membrane swelling, decrease mitochondrial membrane potential, and promote mitochondrial fission). New methods, techniques, and models may better benefit understanding organelle-related drug’s mechanisms. This Research Topic introduces new technologies, models, markers, drugs, and imaging probes to develop organelle research. In addition, this Research Topic will publish original and review articles on current high-impact research novel drugs, methods or techniques used to dissect the pharmacological mechanisms for organelle-related drug development.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Novel drugs, including combination medication, nanomaterials, biomaterials based on organelle targets (such as mitochondria, lysosome, lipid droplets and their interactions).
• New techniques such as nanoscopic imaging, optogenetics, single-molecule imaging, etc., reveal the behaviour of drugs on key molecules in the organelle.
• New analytical methods for organelle quantification.
• New research models using cells, zebrafish, C. elegans, Organoid for organelle-associated diseases.
• Novel imaging probes for organelle imaging and diseases therapy.
Newly developed technologies such as super-resolution imaging, such as stimulated emission depletion (STED), structured illumination microscopy (SIM), and stochastic optical reconstruction microscopy (STORM), as well as other single-molecule super-resolution imaging techniques, are enhanced new tools for investigating the dynamics of subcellular structures, including mitochondria. Combining functional fluorescent probes, optogenetics, and photodynamic therapy with super-resolution imaging is an excellent strategy for clarifying the underlying pathology for organelle associated drugs such as small molecular (functional inhibitors, natural active products, etc.) and macromolecules (peptides, proteins, antibodies, glycans, nucleic acids, etc.).
To achieve antitumor effects, drugs can induce organelle responses such as mitochondrial (membrane swelling, decrease mitochondrial membrane potential, and promote mitochondrial fission). New methods, techniques, and models may better benefit understanding organelle-related drug’s mechanisms. This Research Topic introduces new technologies, models, markers, drugs, and imaging probes to develop organelle research. In addition, this Research Topic will publish original and review articles on current high-impact research novel drugs, methods or techniques used to dissect the pharmacological mechanisms for organelle-related drug development.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Novel drugs, including combination medication, nanomaterials, biomaterials based on organelle targets (such as mitochondria, lysosome, lipid droplets and their interactions).
• New techniques such as nanoscopic imaging, optogenetics, single-molecule imaging, etc., reveal the behaviour of drugs on key molecules in the organelle.
• New analytical methods for organelle quantification.
• New research models using cells, zebrafish, C. elegans, Organoid for organelle-associated diseases.
• Novel imaging probes for organelle imaging and diseases therapy.
Keywords: Organelle, mitochondria, lysosome, drug, anti-tumor, imaging, nanoscopic, theranostics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
