About this Research Topic
Invasive candidiasis is an emerging infection closely linked to advances in medical technology, solid-organ transplant recipients, and patients with solid tumor requiring chemotherapy. It is widely recognized as a major cause of morbidity and mortality in the health-care environment. Invasive candidiasis also results in large direct healthcare costs because of its severity.
Candida spp. are common fungal microorganisms that colonize the oral, genital and gastrointestinal surfaces of most healthy individuals. In immunocompromised patients, Candida spp. may disseminate into the bloodstream, causing life-threatening invasive candidiasis. The interplay between host, Candida spp., and anti-Candida infectives determines the clinical prognosis of invasive candidiasis. This Research Topic, covering the pathogenicity of Candida, host immune responses to Candida, the mechanisms of immune escape of Candida, the mechanisms of drug activity against Candida and the drug resistance development of Candida, hopes to highlight new strategies and agents for the treatment of Candida infections.
In this Research Topic, we welcome Original Research articles, Mini Reviews, Reviews, Hypothesis, Theory and Perspectives covering invasive candidiasis in humans and animals. This Research Topic intends to instigate the discussion and presentation of new relevant research about the virulence traits of Candida spp., especially of the key pathogenic factors, and the interaction between the host and the fungal pathogens, including the innate immune response and adaptive immune response.
This Research Topic will include, but is not limited to:
- Investigations about the mechanisms of yeast to hyphal transition and biofilm formation.
- Investigations about the mechanisms of adherence and invasion of Candida spp. enabling their dissemination into the bloodstream.
- Studies on the structure and function of fungal cell wall proteins, especially virulence factors
- Immune response mechanisms of the host to Candida spp. and escape mechanisms of Candida spp. from the host
- Mechanisms of action of new anti-Candida compounds
- Drug resistance mechanisms of Candida spp.
- Research on novel therapeutic strategies of invasive candidiasis, especially immunotherapeutic approaches are welcome.
Candida spp. are common fungal microorganisms that colonize the oral, genital and gastrointestinal surfaces of most healthy individuals. In immunocompromised patients, Candida spp. may disseminate into the bloodstream, causing life-threatening invasive candidiasis. The interplay between host, Candida spp., and anti-Candida infectives determines the clinical prognosis of invasive candidiasis. This Research Topic, covering the pathogenicity of Candida, host immune responses to Candida, the mechanisms of immune escape of Candida, the mechanisms of drug activity against Candida and the drug resistance development of Candida, hopes to highlight new strategies and agents for the treatment of Candida infections.
In this Research Topic, we welcome Original Research articles, Mini Reviews, Reviews, Hypothesis, Theory and Perspectives covering invasive candidiasis in humans and animals. This Research Topic intends to instigate the discussion and presentation of new relevant research about the virulence traits of Candida spp., especially of the key pathogenic factors, and the interaction between the host and the fungal pathogens, including the innate immune response and adaptive immune response.
This Research Topic will include, but is not limited to:
- Investigations about the mechanisms of yeast to hyphal transition and biofilm formation.
- Investigations about the mechanisms of adherence and invasion of Candida spp. enabling their dissemination into the bloodstream.
- Studies on the structure and function of fungal cell wall proteins, especially virulence factors
- Immune response mechanisms of the host to Candida spp. and escape mechanisms of Candida spp. from the host
- Mechanisms of action of new anti-Candida compounds
- Drug resistance mechanisms of Candida spp.
- Research on novel therapeutic strategies of invasive candidiasis, especially immunotherapeutic approaches are welcome.
Keywords: invasive candidiasis, immune response, cell wall proteins, virulence factor, treatment
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
