About this Research Topic
Liver fluke infestation and cholangiocarcinoma (CCA) remain one of the major health problems of populations in the northeast of Thailand, as well as the neighboring countries, Laos, Vietnam and Cambodia. In Thailand alone, over 6 million people harbor the liver fluke Opisthorchis viverrini. Infection with this parasite is the major risk factor for developing CCA. The highest incidence of CCA worldwide are found in north and northeast Thailand, reaching between 98.8 and 317.6/100,000/year at ages above 35 years depending on the district examined The Cholangiocarcinoma Research Institute (CARI) of Khon Kaen University is now running the program called “Cholangiocarcinoma Screening and Care Program (CASCAP)” with the aim of establishing a comprehensive program for the long-term control and elimination of liver fluke infection and CCA in Thailand and has been now expanded to the other Southeast Asian countries that share the same burden.
This Research Topic welcome submission of the original articles, which focus on the up-to-date works related to liver fluke and CCA control at primary, secondary and tertiary levels. Moreover, knowledge and innovations for prevention, screening, surveillance, diagnosis and treatment of the liver fluke and CCA problems will be included and structured as follows:
• Novel approaches for the long-term measures for the prevention and control of opisthorchiasis in endemic communities
• Novel approaches for the risk assessment of CCA
• Carcinogenesis of CCA caused by infection and inflammation in order to develop prevention and therapeutic approaches
• The development of treatment and care approaches for CCA patients to improve their quality of life
• Development of a new diagnostic platform for CCA in the northeast of Thailand
This Research Topic welcome submission of the original articles, which focus on the up-to-date works related to liver fluke and CCA control at primary, secondary and tertiary levels. Moreover, knowledge and innovations for prevention, screening, surveillance, diagnosis and treatment of the liver fluke and CCA problems will be included and structured as follows:
• Novel approaches for the long-term measures for the prevention and control of opisthorchiasis in endemic communities
• Novel approaches for the risk assessment of CCA
• Carcinogenesis of CCA caused by infection and inflammation in order to develop prevention and therapeutic approaches
• The development of treatment and care approaches for CCA patients to improve their quality of life
• Development of a new diagnostic platform for CCA in the northeast of Thailand
Keywords: Opisthorchiasis, Cholangiocarcinoma, Global Health, Infection
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