Organelles, which are specialized subunits inside cells, play a unique function in maintaining cell homeostasis. They can communicate with one another and coordinate their activities. In neurodegenerative diseases, many organelles, including mitochondria, endosomes, lysosomes, and nucleus, fail to function correctly. However, how information is transmitted between organelles in neurodegenerative diseases is still unclear. Understanding the intermediate molecules that link organelles in neurodegenerative diseases will provide us new insights for developing novel therapeutical treatments.

Lysosomes are dynamic organelles that participate in cellular homeostasis by serving as the terminal degradative compartment in autophagy, modulating nutrient status and interacting with other organelles. Cathepsins, a group of acid protease localized in endosomes/lysosomes, are translocated from lysosomes to cytosol and nucleus or mitochondria, leading to dysfunction of targeted organelles in microglia. However, many other mechanisms of intermediate molecules that link organelles in neurodegeneration are still unrevealed.

This Research Topic aims to explore and highlight recent studies on pathological roles of intermediate molecules that link organelles, including lysosomes, mitochondria, nucleus, Golgi complexes and endoplasmic reticulum, in neurodegenerative diseases, such as Alzheimer’s disease, Parkinson disease, Huntington’s disease, and Amyotrophic lateral sclerosis. Moreover, this Research Topic would also like to focus on potential therapeutic approaches that target intermediate molecules that link organelles in neurodegenerative diseases.

We welcome original research articles and reviews that related to the following topic:
- Identifying intermediate molecules and molecular mechanisms in the crosstalk between organelles in neurodegenerative diseases.
- Developing and implementing bioinformatics tools to study factors involving in the communication of organelles in neurodegenerative diseases.
- Investigating the regulation of the intermediate molecules in neuronal and non-neuronal cells, including neurons, microglia, astrocyte, and oligodendrocyte, as well as the peripheral cells which affect neurodegenerative diseases.
- Exploring the intervention of specific intermediate molecules mediated pathologies in neurodegenerative diseases.

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Frontiers in Neuroscience

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