About this Research Topic
γδ T cells are innate-like T cells that serve as an important component in the immune systems of all jawed vertebrates. Under physiological conditions, γδ T cells are identified as an important population in the surveillance of stressed cells, maintenance of tissue homeostasis and intact thermogenesis as well as healthy social behavior. In pathological conditions such as tumor, infection and inflammatory diseases, γδ T cells often contribute to early immune reactions and serve as a vital bridge between the innate immune response and adaptive immune response. The above functions of γδ T cells were carried out via surface innate receptors, secreted cytokines and/or cytotoxic particles. In short, γδ T cells are a functionally heterogeneous population which is necessary for a consummate physiology as well as an intact immune response in pathology. Although significant progresses have been made regarding the functional heterogeneity of γδ T cells, they remain an enigmatic cell population since much less is known about its’ developmental trajectory, subsets programming, antigen recognition, peripheral differentiation as well as communications with other cell types under both physiological and pathological conditions.
The goal of this Research Topic is to provide a forum to advance research on expanding the functional aspects of γδ T cells under both physiological and pathological conditions, to uncover the molecular mechanisms underlying the development, programming, antigen recognition, peripheral differentiation and intercellular communications of γδ T cells as well as to explore innovative γδ T cell immunotherapies in the attempt to achieve a beneficial impact on human diseases or animal models.
We welcome submissions of Original Research, Review and Mini Review on the sub-topics below:
• Novel functions of γδ T cells under either physiological or pathological conditions.
• The developmental trajectory and thymic programming of γδ T cell subsets.
• The molecular mechanisms underlying the tissue-specific distribution of γδ T cells.
• The migration, antigen recognition and activation of γδ T cells under either physiological or pathological conditions.
• The intercellular communication of γδ T cells with γδ T cell subsets, B cells, NK/NKT cells, ILCs, myeloid cells or non-immune cells.
• Prophylactic and/or therapeutic immune strategies based on γδ T cells for human diseases or animal models.
• Innovative methods or antibodies for analysing γδ T cell compartments.
The goal of this Research Topic is to provide a forum to advance research on expanding the functional aspects of γδ T cells under both physiological and pathological conditions, to uncover the molecular mechanisms underlying the development, programming, antigen recognition, peripheral differentiation and intercellular communications of γδ T cells as well as to explore innovative γδ T cell immunotherapies in the attempt to achieve a beneficial impact on human diseases or animal models.
We welcome submissions of Original Research, Review and Mini Review on the sub-topics below:
• Novel functions of γδ T cells under either physiological or pathological conditions.
• The developmental trajectory and thymic programming of γδ T cell subsets.
• The molecular mechanisms underlying the tissue-specific distribution of γδ T cells.
• The migration, antigen recognition and activation of γδ T cells under either physiological or pathological conditions.
• The intercellular communication of γδ T cells with γδ T cell subsets, B cells, NK/NKT cells, ILCs, myeloid cells or non-immune cells.
• Prophylactic and/or therapeutic immune strategies based on γδ T cells for human diseases or animal models.
• Innovative methods or antibodies for analysing γδ T cell compartments.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
