Locoregional Management of Breast Cancer: Multidisciplinary and Individualized Treatment

Breast cancer is the most frequent malignancy and the second most frequent cause of cancer related death in women. The improvements in the locoregional management of breast cancer have brought decreased trauma, elevated quality of life, and new challenges open to answer. As an essential part of locoregional management, surgical techniques have evolved towards the minimum invasiveness, including solidification of breast conservation as the preferred option for eligible patients, also increased oncoplastic surgery and breast reconstruction to optimize cosmetic outcomes. The de-escalation of local therapy and optimal surgical margin has also drawn great interest. On the other hand, recent advances in whole-breast and partial-breast irradiation techniques add to the standard of care for breast cancer patients. In addition, a comprehensive evaluation of the individual including novel genetic testing, clinicopathological factors, multigene assays, imaging, etc. enhanced the understanding of tumor biology and clinical manifestations, also offering great information to guide individualized locoregional management. Herein, this current issue of Frontiers in Oncology tells the story of advances and actuality of the locoregional management of breast cancer, especially focusing upon the role of multidisciplinary teamwork and individualized therapy.

This topic aims to present the advances and actuality of the locoregional management for breast cancer, focusing on the multidisciplinary collaboration in the development of locoregional treatment strategies. With joint efforts of the multidisciplinary team, we will be able to gain a better understanding of tumor behaviors to guide the escalation or de-escalation of certain therapies, to select the optimal treatment for the individual. We hope to ultimately keep remarkable locoregional control while improving the quality of life and value of treatment for breast cancer patients.

We welcome contributions of Original Research, Clinical Trial, Systematic Review, Mini Review, Novel Methods, Hypothesis and Theory encompassing clinical, translational, and basic researches focusing on the multidisciplinary and individualized locoregional management of breast cancer. Topics of interest include, but not limited to, the following aspects:
• Genetic testing to guide locoregional decisions of breast cancer patients
• De-escalation of locoregional treatment for ductal carcinoma in situ and early invasive breast cancer
• Integration of oncoplastic surgery to optimize esthetic outcomes
• De-escalation therapy for regional nodal
• Advances in postmastectomy and regional nodal radiation for breast cancer
• Optimal locoregional management of breast cancer after neoadjuvant therapy
• Multidisciplinary management of locoregional recurrence breast cancer
• Predictive factors for locoregional recurrence of breast cancer
• Imaging evaluation and locoregional management of breast cancer


Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.