About this Research Topic
Cancer is the second leading cause of death globally. Biomarkers play an increasingly important role in predicting cancer risk and in the clinical management of cancer patients. With the development of high-throughput profiling technologies, we could obtain a great amount of cancer-related data, including genetic variation, transcriptome, proteomics, and protein modification omics data. These multidimensional omics data provides a panoramic analysis of cancers. The coding and noncoding genes could format a competing endogenous RNA (ceRNA) network, thus involved in cancer initiation and progression. Computational methods are commonly used in systems biology and the integration of experimental research studies. The application of computational biology facilitated the screening of cancer biomarkers using multi-omics data. Analysis based on the integration of multiple omics data (such as protein expression, ncRNA expression, DNA methylation, etc.) could provide a comprehensive perspective for cancer molecular-level analysis. It would greatly promote the development of tumour precision medicine. Increasing evidence shows that multi-biomarkers (including abnormal gene expression, genetic variation, DNA methylation etc.) are potential prognostic/diagnostic biomarkers and therapeutic targets for cancer.
This Research Topic aims at promoting the understanding of multi-omics markers in tumours and provide new insights for the application of bioinformatics algorithms.
We welcome Original Research articles, Methods, Reviews, Mini Reviews, Perspectives and Opinions on the sub-themes below:
• Genetic and epigenetic traits as prognostic and diagnostic biomarkers for cancer
• The potential of ncRNA as biomarkers in cancer
• Somatic and cell-free DNA methylation as a universal biomarker in cancer
• Identifying novel diagnostic and prognostic biomarkers using multi-omics data
• Integration of multi-omics data in cancer diagnosis and prognosis
• Proteomics for cancer biomarker discovery
• Multi-biomarker in classification and staging of cancer
• Cancer-related diagnostic and prognostic multi-biomarker
• Identification multi-biomarker for cancer diagnosis and prognosis based on biomolecular network
• Application of computational biology in the screening of biomarkers using omics data
• Machine learning methods in the computational biology of cancer
Disclaimer: Authors must be aware that the validation of predictions for biomarkers is the standard for the journal section.
Descriptive studies will not be considered for review unless they are extended to provide meaningful insights into gene/protein function and/or the biology of the subject described. Brief Research Reports, Data Reports, Genome Announcements, Systematic Reviews, and Case Reports will not undergo the peer-review process. Studies that fall into the following categories will also not be considered for review:
• Comparative transcriptomic analyses that report only a collection of differentially expressed genes, some of which have been validated by qPCR under different conditions or treatments;
• Re-analysis of existing genomic and transcriptomic data that attempts to identify a set of diagnostic or prognostic markers for disease.
• Descriptive studies that merely define gene families using basic phylogenetics and assign cursory functional attributions (e.g. expression profiles, hormone or metabolites levels, promoter analysis, informatic parameters).
• Studies consisting of publicly available data to develop predictive models.
• Descriptive studies that only report sequencing data.
Keywords: Multi-biomarker, prognosis, network, bioinformatics, multi-omics data
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
