About this Research Topic
The 2016 World Health Organization (WHO) classification had provided molecular characterization a central role in glioma classification. Significant improvements have been performed in characterizing brain tumors to predict survival outcomes and treatment response. Novel therapeutic approaches, based on cancer biology, are increasingly being used, with promising results on tumor outcome. Despite progress in surgical techniques, molecular characterization, and “target therapy”, prognosis of malignant gliomas remains usually poor and they still lacks effective treatments. This evidence indicates a need for precise parameters to further classifying brain tumors. Our understanding of the molecular pathology of brain tumors has progressed significantly, bringing many benefits in this respect. However, it is necessary to continue this research for more personalized diagnoses and novel therapeutic approaches. Advanced diagnostic strategies may help to better classify brain neoplastic entities and to predict their biological behavior, as prognosis or response to therapy.
The focus of this Research Topic is on the application of novel discovery in characterizing brain tumors for diagnostic, prognostic, or predictive purposes. It is dedicated to answering unsolved diagnostic and biological questions in brain tumors focusing on novel/advanced strategies in imaging, histological, genetic, and molecular analysis and the potential applications of these strategies at bedside. Researchers are encouraged to submit original research articles on the application of novel/advanced techniques in the characterization of brain tumors. Original research and review articles describing the state of the art and systematic reviews on this topic are also encouraged, as well as work in the following areas:
• Brain tumors
• Gliomas
• Brain tumors diagnosis
• Molecular pathology of brain tumors
• microRNA
• Target therapy
• Therapeutic approach in brain tumors
Keywords: Brain, gliomas, molecular markers, histology, therapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
