About this Research Topic
Cardiovascular disease (CVD) is one of the leading causes of mortality and morbidity in the world. Although great progress has been made in cardiovascular research and treatment, CVD still remains a major public health issue with high incidence worldwide. Death of cardiovascular cells plays a critical role in CVD. Programmed cell death (PCD) is death of a cell in any pathological format, mediated by an intracellular program. PCD includes the well-defined apoptosis, and new forms of regulated cell death, such as autophagy, pyroptosis, ferroptosis, paraptosis, and mitotic catastrophy. Appropriate PCD serves fundamental functions during tissue and organ development. Conversely, excessive PCD results in organ damage and dysfunction. PCD of cardiomyocytes with extremely low regenerative capacity weakens the heart, and ensued fibrosis makes the heart stiff and results in diastolic dysfunction. The loss of vasculature cells causes fibrosis and inflammation in the vessel wall, accumulating in stenosis or atherosclerosis. However, it remains to be elucidated if PCD is the critical player in the transition of mild compensatory remodeling of the cardiovascular system to overt disease states. Furthermore, the molecular mechanisms underlying PCD to CVD are still a controversial topic. Therefore, explanations of the role of PCD, especially clarifying the underlying mechanism of PCD in CVD are urgently required.
This research topic focuses on cardiovascular PCD, with an aim of delineating how PCD contributes to the initiation and progression of CVD. Addressing these issues will advance our understanding of PCD pathophysiology in CVD and provide new strategies for CVD treatment.
Contributions addressing the roles and mechanisms of PCD in cardiovascular context are welcome for this research topic, including original articles presenting new findings as well as reviews summarizing the advances of the field. Specific themes include, but are not limited to:
1. Heart failure and PCD
2. Cardiac hypertrophy and PCD
3. Myocarditis and PCD
4. Heart development, congenital heart diseases and PCD
5. Cardiometabolic disorders and PCD
6. Vascular diseases and PCD
This research topic focuses on cardiovascular PCD, with an aim of delineating how PCD contributes to the initiation and progression of CVD. Addressing these issues will advance our understanding of PCD pathophysiology in CVD and provide new strategies for CVD treatment.
Contributions addressing the roles and mechanisms of PCD in cardiovascular context are welcome for this research topic, including original articles presenting new findings as well as reviews summarizing the advances of the field. Specific themes include, but are not limited to:
1. Heart failure and PCD
2. Cardiac hypertrophy and PCD
3. Myocarditis and PCD
4. Heart development, congenital heart diseases and PCD
5. Cardiometabolic disorders and PCD
6. Vascular diseases and PCD
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
