About this Research Topic
There is significant progress made in the field of cartilage, ligament, and bone tissue engineering over the last two decades. We are gaining knowledge of the subtle structure of the bone, cartilage, and ligament. New biomaterials and fabrication techniques are emerging to construct a better bionic scaffold. A variety of cell sources and exogenous biomechanical, biochemical, and biophysical stimuli have made advances towards replicating the native architecture and functional properties. However, a number of major challenges must still be addressed before this technique can reach the clinic, such as cell sourcing, biomimicry, and integration of the bioengineering tissue, host inflammation, and survival of the implant. The safety and efficacy of the bioengineering tissue should be carefully examined.
In this Research Topic, we would like to discuss a variety of questions involving the development of tissue engineering strategies and their clinical translation potentials. For instance, how to find or design bionic materials with similar mechanical and physiological states to the healthy bone, cartilage, and meniscus; how to design and fabricate the scaffold better stimulate native spatial complexity in cell types and tissue organization of the bone and joint; how to create a microenvironment facilitating cells, matrix and vessels to regenerate in bioengineering bone and ligament; and how to construct the complex gradients of the stratified zonal architecture at the interface of the bone-soft tissue and the cartilage.
Any manuscript referring to the questions above and bringing something new to current tissue engineering knowledge in the field of bone and joint are welcomed. We are especially interested in the manuscript in the following scopes:
New materials, such as bioceramics, hydrogels, and nanofibers.
- Strategies to modulate differentiation of the stem cells and redifferentiation of the chondrocytes.
- Advances in additive manufacturing for bone and cartilage tissue engineering scaffolds.
- Regulation of angiogenesis in bone tissue regeneration.
- Translational research of bone and joint tissue engineering.
- Biomechanics of bone and joint injury.
- 3D printing application in bone and joint reconstruction.
- Hydrogels for bone/cartilage joint construction.
- Delivery strategies for tissue induction.
- Bioreactors for constructing functional tissue.
In this Research Topic, we would like to discuss a variety of questions involving the development of tissue engineering strategies and their clinical translation potentials. For instance, how to find or design bionic materials with similar mechanical and physiological states to the healthy bone, cartilage, and meniscus; how to design and fabricate the scaffold better stimulate native spatial complexity in cell types and tissue organization of the bone and joint; how to create a microenvironment facilitating cells, matrix and vessels to regenerate in bioengineering bone and ligament; and how to construct the complex gradients of the stratified zonal architecture at the interface of the bone-soft tissue and the cartilage.
Any manuscript referring to the questions above and bringing something new to current tissue engineering knowledge in the field of bone and joint are welcomed. We are especially interested in the manuscript in the following scopes:
New materials, such as bioceramics, hydrogels, and nanofibers.
- Strategies to modulate differentiation of the stem cells and redifferentiation of the chondrocytes.
- Advances in additive manufacturing for bone and cartilage tissue engineering scaffolds.
- Regulation of angiogenesis in bone tissue regeneration.
- Translational research of bone and joint tissue engineering.
- Biomechanics of bone and joint injury.
- 3D printing application in bone and joint reconstruction.
- Hydrogels for bone/cartilage joint construction.
- Delivery strategies for tissue induction.
- Bioreactors for constructing functional tissue.
Keywords: Tissue engineering, bone, cartilage, ligament, scaffold
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
