When extracellular vesicles (EVs) were discovered for the first time, they have attracted attention because of carrying ferritin. In recent years, studies have found that EVs could affect the functions of target cells by transmitting information and activating cell signaling pathways. Extracellular vesicles have also been proven to play an important role in physiological and pathological processes related to cancer progression and metastasis.

The expression level of proteins is an important feature to distinguish EVs from different sources. Compared with nucleic acids, detection of the differential expressions of EVs proteins is more difficult, and it is easy to carry protein contamination when using conventional protein purification methods. However, with the rapid development of proteomics, the study of specific proteins in exosomes will have great prospects. Proteomics has been playing an increasingly important role in identifying early-stage biomarkers and therapeutic targets. EVs proteomics will contribute greatly to a better understanding of carcinogenesis and tumor progression, and have great prospects for tumor diagnosis and therapeutic drug carrier development.

Our goal of this topic is to fully understand the proteome landscape of various tumor cells and tissues and to explore the potential use of EVs proteomics in tumor diagnosis and treatment.

For this Research Topic, we would like to receive submissions of Original Research and Review articles covering, but not limited to, the following themes:
1. The role of exosome proteins in tumor metabolism
2. Tumour-derived EVs protein modulates immune cell development and maturity
3. Methods and strategies of isolation and purification proteins in EVs
4. Tumour-derived EVs protein change Tumor Genomics
5. EVs protein as the carriers of anti-tumor drugs
6. Proteomics in carcinogenic bacteria and viruses EVs
7. The role of exosome proteins in cancer progression and metastasis
8. Exosome proteins as biomarkers and/or for dominant population selection for immunotherapy

Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.

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Frontiers in Oncology

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