About this Research Topic
The incidence of obesity is increasing worldwide, and research is mainly focused on clarifying the mechanisms underlying energy homeostasis and adiposity dysregulation in obese people. Physiological regulation of appetite is multifactorial involving different hormones, peptides, tissues, and novel mediators. In obese patients, appetite control and satiety signals may be altered by endogenous and exogenous factors.
Dietary patterns characterized by excessive consumption of foods rich in both sugar and fat contribute to the development of obesity. Experimental data suggest a role of a genetic signature associated with an obese phenotype and with hyperphagia (e.g., MC4R deficiency) but these single-gene defects are extremely rare. Clinical data do not support the proportion of obesity prevalence in the modern population to be mainly due to a genetic predisposition.
In this perspective, collecting evidence on appetite and satiety dysregulation in the pathogenesis of obesity is crucial to develop novel therapeutic strategies, including pharmacological and non-pharmacological treatments to synergically counteract the obesity epidemic.
In this Research Topic we welcome submissions of Original Research, Review and Mini-Review articles focused on but not limited to the following topics:
1. Central nervous system control of energy balance and how it can be overridden by hedonic/reward circuits.
2. Effects of sugar and fat consumption on neurotransmission.
3. Dysregulated feeding behavior due to constantly available palatable, high-sugar, and high-fat food products.
4. Physical inactivity/activity and effects on appetite control.
5. Eating frequency and eating patterns promoting constant elevated gastrointestinal hormones, thus keeping obese individuals in ‘’fat-storing'' mode.
6. Dietary interventions and effects on satiety signals.
Dietary patterns characterized by excessive consumption of foods rich in both sugar and fat contribute to the development of obesity. Experimental data suggest a role of a genetic signature associated with an obese phenotype and with hyperphagia (e.g., MC4R deficiency) but these single-gene defects are extremely rare. Clinical data do not support the proportion of obesity prevalence in the modern population to be mainly due to a genetic predisposition.
In this perspective, collecting evidence on appetite and satiety dysregulation in the pathogenesis of obesity is crucial to develop novel therapeutic strategies, including pharmacological and non-pharmacological treatments to synergically counteract the obesity epidemic.
In this Research Topic we welcome submissions of Original Research, Review and Mini-Review articles focused on but not limited to the following topics:
1. Central nervous system control of energy balance and how it can be overridden by hedonic/reward circuits.
2. Effects of sugar and fat consumption on neurotransmission.
3. Dysregulated feeding behavior due to constantly available palatable, high-sugar, and high-fat food products.
4. Physical inactivity/activity and effects on appetite control.
5. Eating frequency and eating patterns promoting constant elevated gastrointestinal hormones, thus keeping obese individuals in ‘’fat-storing'' mode.
6. Dietary interventions and effects on satiety signals.
Keywords: appetite, hyperphagia, obesity, metabolic syndrome, adiposity
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
