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The global burden of cancer is increasing day by day. Advances in molecular technologies have enabled researchers to delineate the mechanism of carcinogenesis at the molecular level. Multi-omics technologies (genomics, epigenomics, transcriptomic, and proteomics) have contributed to the overall understanding of cancer as a whole system. Thanks to these advanced technologies, researchers can now identify specific molecular signatures caused by a particular carcinogenic compound. Moreover, the ability to detect cancer-specific molecular alterations in a highly sensitive manner is crucial for the advancement of liquid biopsy and also for the early detection of cancer.

The ultimate goal of this research topic is to provide a platform for sharing the latest research findings on different molecular biomarkers and how they may be applied to the detection, diagnosis, and prognosis of cancer. Recent advances in liquid biopsy, single-cell sequencing, and functional analysis of genetic association studies using genomics, transcriptomics, epigenomics, proteomics, and metabolomics have enhanced the potential of molecular biomarkers to change the current management protocols of cancer. This issue targets these special areas of cancer research to provide up-to-date knowledge on this field. This will provide the cancer researchers working throughout the world, a perfect platform to share their exciting findings.

This Research Topic aims to present and discuss the most recent findings associated with novel molecular biomarkers, and how they may be applied to cancer treatment and diagnostics. Areas of interest include, but are not limited to, the following:

• Genomic and Epigenomic biomarkers of cancer

• Proteomic and metabolomic biomarkers of cancer

• Liquid biopsy of cancer

• Transcriptomics in cancer

• Genetic association studies

Impact

Frontiers in Molecular Biosciences

Molecular Diagnostics and Therapeutics