About this Research Topic
Mass spectrometry (MS) has become the method of choice for bioanalysis, including disease diagnostics, protein analysis, proteomics, and lipidomics, due to its high detection sensitivity, high specificity and high speed of analysis. In particular, the capability of mass analysis is constantly improving towards high mass resolution, high sensitivity, and better characterization of biomolecules and other compounds, including proteins, peptides, lipids, and pharmaceuticals. Moreover, ion mobility is also very successful when coupled with MS for the analysis of proteins, peptides, lipids and pharmaceuticals. Such studies have substantially contributed to analytical and bioanalytical chemistry, e.g. rapid bioanalysis, biological studies and disease diagnostics, and bring about great potentials in their diverse applications.
We envisage that new methodology and applications capable of quantitative and qualitative analysis of biomolecules will attract increased research interest, leading to improved bioanalysis, environmental analysis and disease diagnostics, et al. Such methods and applications will also be instrumental to range of fundamental studies, such as protein-protein interaction and protein-ligand interactions. This Research Topic aims to become the point of reference for the latest advances in quantitative and qualitative analysis of biomolecules using mass spectrometry, as well as the progress in sample pretreatment and ionization prior to MS analysis.
We welcome Original Research, Review, Mini Review, and Perspective articles on developing novel strategies for the characterization of biomolecules using mass-spectrometry-based techniques for various applications, such as environmental monitoring, drug screening, and disease diagnostics. Specific themes may include, but not limited to:
• Novel methodology around the qualitative and quantitative analysis of biomolecules, such as proteins and lipids, with mass spectrometry
• Development of green analytical protocols for MS analysis
• Analysis of peptides, proteins, lipids, and pharmaceuticals towards disease diagnostics and biological studies, using mass spectrometry
• Molecular identification and quantification of biomolecules towards disease diagnostics using ion mobility mass spectrometry
• Chemical profiling and quantitative bioanalysis, using hyphenating techniques coupling chromatography (e.g., LC, GC, and SFC) with MS, ambient mass spectrometry et al, to enable sensitive or sample treatment-free MS analysis.
• High resolution MS imaging for the highly selective and sensitive imaging of biological tissues
We envisage that new methodology and applications capable of quantitative and qualitative analysis of biomolecules will attract increased research interest, leading to improved bioanalysis, environmental analysis and disease diagnostics, et al. Such methods and applications will also be instrumental to range of fundamental studies, such as protein-protein interaction and protein-ligand interactions. This Research Topic aims to become the point of reference for the latest advances in quantitative and qualitative analysis of biomolecules using mass spectrometry, as well as the progress in sample pretreatment and ionization prior to MS analysis.
We welcome Original Research, Review, Mini Review, and Perspective articles on developing novel strategies for the characterization of biomolecules using mass-spectrometry-based techniques for various applications, such as environmental monitoring, drug screening, and disease diagnostics. Specific themes may include, but not limited to:
• Novel methodology around the qualitative and quantitative analysis of biomolecules, such as proteins and lipids, with mass spectrometry
• Development of green analytical protocols for MS analysis
• Analysis of peptides, proteins, lipids, and pharmaceuticals towards disease diagnostics and biological studies, using mass spectrometry
• Molecular identification and quantification of biomolecules towards disease diagnostics using ion mobility mass spectrometry
• Chemical profiling and quantitative bioanalysis, using hyphenating techniques coupling chromatography (e.g., LC, GC, and SFC) with MS, ambient mass spectrometry et al, to enable sensitive or sample treatment-free MS analysis.
• High resolution MS imaging for the highly selective and sensitive imaging of biological tissues
Keywords: mass spectrometry, structure elucidation, biomolecules
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