Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to detoxify reactive intermediates or to repair the resulting damage. Antioxidants are molecules that inhibit or quench free radical reactions, which then delay or inhibit cellular damages. They are divided into metabolic antioxidants and nutrient antioxidants. Metabolic antioxidants, belonging to endogenous antioxidants, are produced in the human body by metabolism. On the other hand, dietary antioxidants, belonging to exogenous antioxidants, are compounds that cannot be produced in the body. Thus, they must be provided through foods or supplements.

The integration of dietary antioxidants in therapy and/or their association with other synergic drugs is still not well understood and it represents a challenge in this area. The aim of this Research Topic is to enforce the proposition of new solutions for natural antioxidant implementation, development, and integration in therapeutic strategies. Synthetic or technological solutions aimed to face the problem of the poor absorption and susceptibility to metabolic transformations of such molecules, are also welcome. Moreover, we encourage submissions based on the synthesis of new molecules bringing natural antioxidants pharmacophores, thus originating new “nature inspired” potential antioxidants.

This Research Topic aims at gathering multidisciplinary Original Research, General Commentary and Review articles coming from chemistry, pharmaceutical technology, molecular biology, pharmacology and translational medicine areas, covering all the crucial aspects connected to the use of natural or nature inspired antioxidants in human health. In particular, we expect submissions on, but not limited to, the following topics:
- Synthetic or technological solutions to improve the antioxidant activity of natural antioxidants;
- Synthesis of new nature inspired molecules, their characterization and their activity/toxicity assessment;
- Evaluation in vitro and in vivo of antioxidant mechanism and biological targets: cellular functions and oxidative damage;
- Technological solutions for therapeutic applications of natural antioxidant, alone or in combination with other drugs.

Papers dealing purely with molecules synthesis and characterization not reporting the scientific proof of the antioxidant activity, or with basic or clinical data not characterized by a multidisciplinary approach will not be considered positively.

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Frontiers in Pharmacology

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