Nanoengineering for drug delivery is an interdisciplinary field in modern pharmacology. It combines nanotechnology and biochemistry to govern the systemic pharmacokinetics of therapeutic agents and ultimately shifts from fundamental concepts to translational pharmacology. The technology of nanoengineering for drug delivery aims to resolve the translational challenges of therapeutic agents by modifying in vivo stability, drug release profile, absorption, distribution, and elimination. These include poor aqueous solubility, low in vivo stability, limited blood-circulation time, side effects, and barriers to target-site delivery. A well-nanoengineered drug delivery entity comprises tunable physicochemical properties, desirable biocompatibility, and safety, being able to deliver therapeutic agents to the target-site with prominent efficacies for the diagnostic or treatment of diseases.

Current efforts in nanoengineered drug delivery involve the nanoengineering novel strategies in target-oriented drug delivery, site-specific and sustained drug release, multidrug delivery for synergistic therapy, and theranostic-based supervised drug delivery. Most recently, the nanoengineering of the delivery system in systemic transportation of biomacromolecules and immunotherapeutic agents (such as genome-editing systems, mRNAs, antibodies, epitopes) has gained considerable momentum. Thus far, many novel nanoengineered delivery systems have been developed, such as micelles, liposomes, dendrimers, lipid nanoparticles, metal-organic frameworks, nanodiscs, exosomes, and bio-membrane vesicles. Although there are several drug delivery systems that have been successfully employed in the clinical setting, there are still specific crucial challenges that need to be addressed (as mentioned above); therefore, an advanced nanoengineering technology needs to be developed to meeting the evolving needs of precision and future medicine.

Regarding the nanoengineering in drug delivery, the designed system must minimize potential negative impacts that arise from nanotoxicity, biocompatibility, immunogenicity, and degradability. Besides, a promising nanoengineered delivery system should avoid sophisticated chemical synthesis and nanostructure modifications because this may lead to the difficulty of obtaining stoichiometry and reproducibility challenges. These inconsistencies could lead to variable treatment outcomes and adverse effects on subjects. It is believed that the rational and minimal design of the nanoengineered delivery system is more expected towards clinical translation.

In this Research Topic, we will fundamentally focus on the novel design and nanoengineering of drug delivery systems by chemical, material, and biological approaches, which could promote the development of advanced drug delivery systems towards clinical translation. This Research Topic is tending to provide advanced solutions to address the ongoing challenges associated with limited blood-circulation time, adverse effects, multidrug resistance, targeted delivery, controlled release, multidrug delivery, and systemic biomacromolecules delivery. The innovative nanoengineering approaches for translational research will motivate and inspire academic communities and the pharmaceutical industry to accelerate these interdisciplinary developments and their translation to clinical uses.

The main scope of the current Research Topic focuses on innovative nanoengineering strategies and applications in advanced drug delivery and translational research. Types of manuscripts to be featured include Original Research, Methods, Protocols, Review, and Perspective articles. Themes to be investigated may include, but are not limited to:
• Stimuli-responsive drug delivery systems
• Polymeric drug delivery systems.
• Bio-inspired drug delivery systems
• The reverse design of novel drug delivery systems
• Exosomes or cell-derived nanovesicles for translational research
• Nanomedicine for prophylactic and therapy of acute/chronic diseases
• Nanotheranostics facilitated translational medicine
• Bio-nanoengineered nanotheranostics

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Frontiers in Bioengineering and Biotechnology

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