About this Research Topic
Genome variation refers to differences in DNA structure and composition between individuals or between populations, which occur in many common disease types. In the past ten years, GWAS has promoted the progress of gene structure annotation in common diseases and made certain discoveries. With the gradual improvement of genome annotations, multiple sources of disease-related genomic variation have been identified, providing opportunities for us to further understand the regulatory mechanisms of complex diseases and discover new therapeutic targets. And the identification of individual genomic variation will help provide more personalized treatment plans and promote the development of precision medicine.
In this Research Topic, we welcome studies on analysing the genetic variations related to complex diseases and precision medicine.
The concept of precision medicine is finally realized and is now firmly embedded in ongoing drug development projects. The realization of precision medicine is inseparable from a full understanding of complex disease mechanisms. As a new window into the biology of disease, the identification of molecular-level variations in complex diseases will help to understand the pathogenesis and provide guidance for precision medicine.
Potential topics include but are not limited to the following:
• High-throughput sequencing research to identify functional genomic variations such as SNPs, somatic mutations and copy number variation in complex diseases.
• Systematic analysis of biological networks affected by genomic variations to dissect complex disease pathology.
• Experimental research of the effect of genomic variation on personalized disease phenotypes.
• Novel methods and computational approaches to identify genomic variation-drug relations and highlight personalized treatments.
Please note that in line with journal requirements, analysis of data to predict a biomarker for disease requires biological validation of predictions.
In this Research Topic, we welcome studies on analysing the genetic variations related to complex diseases and precision medicine.
The concept of precision medicine is finally realized and is now firmly embedded in ongoing drug development projects. The realization of precision medicine is inseparable from a full understanding of complex disease mechanisms. As a new window into the biology of disease, the identification of molecular-level variations in complex diseases will help to understand the pathogenesis and provide guidance for precision medicine.
Potential topics include but are not limited to the following:
• High-throughput sequencing research to identify functional genomic variations such as SNPs, somatic mutations and copy number variation in complex diseases.
• Systematic analysis of biological networks affected by genomic variations to dissect complex disease pathology.
• Experimental research of the effect of genomic variation on personalized disease phenotypes.
• Novel methods and computational approaches to identify genomic variation-drug relations and highlight personalized treatments.
Please note that in line with journal requirements, analysis of data to predict a biomarker for disease requires biological validation of predictions.
Keywords: Genomic variation, high-throughput sequencing, precision medicine, complex disease
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