Cleft lip and palate (CLP) anomalies/syndromes are integrated in different subjects of medicine and dentistry. An abundance of research is ongoing in this field.

Any deformities (anatomical or chromosomal) that are initiated during pregnancy, with their effects being detected at birth, are considered as congenital anomalies. Among them, CLP is one of the most common congenital anomalies in the head and neck region and only second to congenital heart disease in the whole body with varied prevalence in different civilizations and races. The World Health Organization (WHO) has recognized and included cleft deformities in their Global Burden of Disease initiative. It is estimated that the overall global prevalence of cleft deformities is one affected individual in every 600 newborn babies. Though the exact etiology of CLP is controversial, it is believed that both genetic and environmental factors play an important role. It affects psychological development, causes aesthetic and functional problems such as feeding, speech, hearing, and dental functioning. In addition, it may also contribute in dentoskeletal abnormalities such as maxillary arch constriction (maxillary growth retardation), class III malocclusion, mid facial growth deficiency, congenitally missing and malformed teeth, and other orthodontic anomalies like crowding, rotation, malposition of teeth.

Medical, surgical, dental, speech, and allied health in cleft lip and palate anomalies/syndromes are of utmost importance in the clinical, epidemiological and research field. The diverse and complex needs of patients with cleft lip and palate anomalies/syndromes, and the obligatory facilities of many varied professionals warrants a multidisciplinary approach for successful management.

This Research Topic targets the acquisition and dissemination of knowledge regarding all aspects (including etiology, prevention, diagnosis, treatment and its outcome) of cleft lip and palate anomalies/syndromes to share knowledge from both the basic and clinical sciences.

Topics for submissions include but are not limited to:
• Virtual craniofacial anatomy and morphometry of cleft defects visualized from medical imaging,
• Congenital and acquired cleft morphology and their roles in the prosthetic management,
• Roles of digital workflow in identifying and rehabilitating palatal defects occurring as a result of neoplasms and infections,
• Regenerative medicine and bioprostheses used in the management of cleft defects,
• Artificial intelligence as an aid to assess dental and craniofacial characteristics of cleft lip and palate and craniofacial syndrome patient,
• Treatment indexes to utilize the treatments outcome of cleft lip and palate patient,
• Neurodegenerative problems and genetic researches in cleft lip and palate anomalies/syndromes,
• Effects of various congenital and phenotype factor in cleft lip and palate anomalies/syndromes,
• Airway morphometry and its changes in cleft lip and palate anomalies/syndromes,
• Benchmarking speech, velopharyngeal function outcomes and surgical characteristics in cleft lip and palate anomalies/syndromes,
• Quality of life – exploring the experiences in cleft lip and palate anomalies/syndromes.

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Frontiers in Physiology

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