About this Research Topic
There is a wide variation in biomarkers of exposure, effect, and susceptibility associated with exposure to toxic compounds, despite similar levels of exposure. This is hypothetically related to gene interactions in the kinetics and dynamics of these compounds, resulting in disturbances of redox status, apoptosis, cell death, alterations of epigenetic status, DNA-damage and cancer. However, very little is known about gene-toxicant interactions and their mechanisms of toxicity, as well as underlying effects related to co-exposure to these toxic compounds.
We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the mechanisms underlying toxicant-induced disturbances on redox status, apoptosis, cell death and DNA-damage either in laboratory models (in vitro and in vivo) or exposed individuals. We are particularly interested in articles describing mechanisms and interactions that may modulate the toxicity induced by inorganic (such as metals and metalloids) and organic toxicants (emerging contaminants, endocrine disruptors compounds and pesticides, for example). Studies involving exposed individuals (environmental and occupational) are especially welcome.
Potential topics include, but are not limited to:
- Recent developments on toxicology studies related to inorganic and organic compounds;
- Mechanisms of toxicant-induced DNA-damage, disturbances of redox status and cell death;
- New outcomes related to genetic variations such as polymorphisms and epigenetic events that can modulate toxicity;
- Impact of inorganic and organic exposure on gene expression (genomics and proteomics approaches) and their roles on biological systems;
- New epigenetic biomarkers for inorganic and organic exposure;
- Studies about gene-toxicants, as well as gene-gene interactions in subjects exposed to inorganic and organic compounds.
We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the mechanisms underlying toxicant-induced disturbances on redox status, apoptosis, cell death and DNA-damage either in laboratory models (in vitro and in vivo) or exposed individuals. We are particularly interested in articles describing mechanisms and interactions that may modulate the toxicity induced by inorganic (such as metals and metalloids) and organic toxicants (emerging contaminants, endocrine disruptors compounds and pesticides, for example). Studies involving exposed individuals (environmental and occupational) are especially welcome.
Potential topics include, but are not limited to:
- Recent developments on toxicology studies related to inorganic and organic compounds;
- Mechanisms of toxicant-induced DNA-damage, disturbances of redox status and cell death;
- New outcomes related to genetic variations such as polymorphisms and epigenetic events that can modulate toxicity;
- Impact of inorganic and organic exposure on gene expression (genomics and proteomics approaches) and their roles on biological systems;
- New epigenetic biomarkers for inorganic and organic exposure;
- Studies about gene-toxicants, as well as gene-gene interactions in subjects exposed to inorganic and organic compounds.
Keywords: DNA damage, DNA methylation, emerging contaminants, toxic metals, microRNAs
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
