About this Research Topic
At the single-cell level, cells must regulate their own growth and behavior by translating environmental stimuli into signals that regulate gene expression and function. Vesicles continually bud off from one membrane and fuse with another. This vesicular trafficking flows along highly organized, balanced and directional routes from the endoplasmic reticulum (ER) towards the Golgi apparatus and cell surface or to lysosomes known as the biosynthetic-secretory pathway this continues to the plasma membrane to early endosomes which then becomes recycled to the surface to be reused or degraded via the endocytic pathway. Disorders in this finely organized vesicular trafficking in and out of the cells is a hallmark of cancer and in a myriad of disease states.
This Research Topic aims to provide deeper insights into how cellular communication occurs between the compartments through vesicles in both physiological and pathological settings. We encourage the submission of Original Research and Reviews articles dissecting the role of vesicular trafficking in mammalian homeostasis and disease. Areas to be covered may include, but are not limited to:
• Trafficking machinery and regulators (microtubules and microtubule associated proteins, Rab-GTPases, PI3Ks, tethering factors and SNAREs)
• Signaling
• The role of oxidative stress and metabolism
• Autophagy
• RNA and organelle transport
• Alteration of vesicular trafficking in disease
• Methods: How to study vesicular trafficking
Keywords: Vesicular Trafficking, Organelle transport, Membrane Trafficking
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.