About this Research Topic
Research on the molecular mechanisms underlying the multiple actions displayed by melatonin, as well as in vitro, in vivo and clinical findings, support its broad protective potential against several pathologies. Given its multiple functions, reductions of local melatonin have increasingly been considered to be contributor of a large number of diseases with the melatonergic system becoming of paramount importance in the development and expansion of them. In this context, despite of having a great amount of scientific evidence which appears to show that melatonin is safe, even at high doses, additional studies are required to translate the therapeutic potential of melatonin to clinical practice.
This Research Topic will serve as a forum to bring together researchers of different fields to advance in the knowledge of the therapeutic use of melatonin and clinical aspects of melatonin in human health. Original Research and General Commentaries will be particularly welcomed. Case Reports, Clinical Trials, Mini Reviews and Reviews, which present comprehensive research in relation to melatonin, are encouraged.
In this Research Topic we hope to assemble a series of articles covering topics which could include, but are not limited to:
• Clinical application and the implications of melatonin as a promising therapeutic agent;
• Molecular mechanisms underlying the actions displayed by melatonin in the onset and evolution of can-cer;
• Use of the melatonin for a possible therapeutic approach against infectious diseases (clinical intervention for the management of the current COVID-19 outbreak);
• Melatonin as adjuvant for the development of novel therapeutic strategies;
• Melatonin as a therapeutic strategy to reduce the multiplicity of effects in neurodegenerative pathologies of brain ischemia;
• Regulation of mitochondrial bioenergetics by melatonin in health and disease.
Keywords: Melatonin, therapeutic, adjuvant, antioxidant, disease
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.