About this Research Topic
The use of microbial cell factories or multi-enzyme molecular machines for biomanufacturing needs to consider both technological and economic feasibility. To satisfy industrial production metrics TRY (i.e., titer, rate, and yield), it is necessary to consider:
- Designing the synthetic pathways;
- Analyzing and optimizing the multi-enzyme regulations;
- Characterizing of cell physiological performance and metabolic responses;
- Mining enzyme resources and evolving enzyme activities for building novel biocatalysts.
Here, systems biology, evolution engineering, and synthetic biology have to be integrated to construct new microbial cell factories or multi-enzyme molecular machines with a high chance of industrial success.
The purpose of this Research Topic is to highlight the recent progress and trends in the development of efficient biomanufacturing via microbial cell factories or multi-enzyme molecular machines. Manuscript submissions in the related areas are welcome. Potential topics include, but are not limited to:
- Microbial cell factory
- Multi-enzyme molecular machine
- Whole-cell biocatalysis
- Metabolic engineering
- Genome editing
- Enzyme engineering
- Cell-free systems
- Computer-aided strain development and process engineering
Keywords: biomanufacturing, synthetic biology, system biology, microbial cell factories, multi-enzyme molecular machines
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.